Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus and Vascular Complications: A Comparative Study

Abstract

Type 2 diabetes mellitus (T2DM) is a common metabolic illness linked to serious vascular consequences, such as coronary artery disease, acute ischaemic stroke, and diabetic retinopathy. As a potential biomarker for platelet activation and its role in T2DM-related vascular problems, Mean Platelet Volume (MPV) has attracted attention.

Methods: This study enrolled 120 T2DM patients between January 2021 and June 2022, a period of 18 months. Group A (T2DM with vascular issues) and Group B (T2DM without vascular complications) were used to stratify the study population. To determine differences between the two groups, this study used automated hematology analyzers to quantify MPV levels and perform statistical analysis.

Results: According to current research, patients in Group A had MPV levels that were considerably greater than those in Group B (p 0.05). Patients with AICVA had the highest MPV levels, followed by those with CAD and DR, according to subgroup analyses within Group A. Despite not being statistically significant, these trends offer important information.

Conclusion: In conclusion, MPV may be a useful biomarker for determining the likelihood of vascular problems in T2DM. However, to prove its therapeutic importance and utility in everyday practice, prospective trials are crucial. The prompt therapy and prevention of T2DM-related vascular problems could be aided by early detection of high MPV levels, eventually enhancing patient care and outcomes.