Dissolution Rate Enhancement of Lansoprazole Tablet in Hydrophilic Carrier Solid Dispersions by Solvent Evaporation Methods

Abstract

Solid dispersion technique has been developed for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. The objectives of present investigation is to improve the solubility and rate of dissolution of poorly aqueous soluble drug lansoprazole by preparing solid dispersion with hydrophilic carrier Poly Ethylene Glycol 6000, hydroxy propyl methyl cellulose, Polyvinyl pyrrolidone by using solvent evaporation method and selecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion was performed by FTIR and DSC. This study showed no interaction in drug and carrier. The designed granulation method was employed to prepare solid dispersion tablets and the formulation was optimized through investigating the dissolution behaviours. The results indicated PEG and Polyvinyl pyrrolidone in combination of solid dispersion showed the best effect both on physical characterizations and dissolution studies. Furthermore, all type of solid dispersions significantly improved the dissolution rates when compared to pure drug and its corresponding physical mixture (PM). All the evaluations were performed and complies with the pharmacopoeial standards. The formulation F7 showed 98.88% of cumulative drug release within 8 min with zero order release pattern. The solid dispersion tablets prepared in simplified tableting method exhibited better operability, stability and dissolution behaviour than the tablets prepared in traditional ways, which brought more opportunities to solid dispersion technique for industrial production