A Comparative Study of Rapid Trypsinogen 2 Strip Test Versus Serum Amylase and Serum Lipase in Diagnosis of Acute Pancreatitis in A Tertiary Care Hospital, Salem

Abstract

Aims & Objectives:  To assess the diagnostic usefulness of a quick urine trypsinogen 2 strip test to blood amylase and lipase in instances with acute pancreatitis. Methods: Patients who may have an acute pancreatitis diagnosis and have recent onset of stomach pain are included. In these cases, serum samples of amylase and lipase are sent before a urine sample is examined using a dipstick test for urinary trypsinogen-2. Fifty-two participants were included in the research. Ultrasound and CECT abdomen were used to monitor patients and confirm the diagnosis. A number of metrics were computed and compared, including sensitivity, specificity, PPV, NPV, and accuracy. Result: During June 2022 and June 2023, 52 consecutive patients complaining of upper abdominal discomfort were included in the research. Acute pancreatitis was the diagnosed diagnosis in 45 of the 52 patients, whereas other causes of abdominal discomfort were present in 7 individuals. The pee dipstick test was positive in 44 of the 45 instances, but was negative in 5 of the 7 cases when the discomfort in the abdomen was caused by anything other than a urinary tract infection. It was shown to have a 97.78 percent sensitivity, a 71.43 percent specificity, and a 94.23 % accuracy. Conclusion: Acute pancreatitis may be diagnosed quickly and easily with a fast urine trypsinogen-2 test. This study shows that the dipstick test is just as accurate as the gold standard procedures and may be used alternately with them.