Synthesis And Biological Activity Of New Indole Based Derivatives As Potent Anti-Inflammatory Agent
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Abstract
Indole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of action Indole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of actionIndole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of actionIndole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of action In the present work, synthesis and biological activity of new indole based derivatives as potent anti-inflammatory agent. The derivatives were schemed and substituted, they were checked for docking scores against the Cyclooxygenase II enzyme. From that 10 best docked compounds are selected and synthesized spectral data of the synthesized compounds was obtained from IR , 1HNMR, 13CNMR, and mass spectroscopy, among the tested compounds. From the docking results, compound A7 and A10 (9.2 Kcal/mol) shows the highest binding affinity against Cyclooxygenase II enzyme possesses anti-inflammatory activity
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