A Brief Review of the Medicinally Important Indole Derivatives
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Abstract
Indole is an exceptional heterocyclic molecule with a broad spectrum of pharmacological activity owing to various modes of action. It is also a versatile pharmacophore and a favored scaffold. For drug development, it is an excellent moiety whose only characteristic is that it resembles many protein structures. Plenty of research has been taking place in recent years to synthesize and explore the various therapeutic prospective of this moiety. This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring. Some of the most recent efficient chemical synthesis for the indole ring (from 2014 to 2018) is compiled in this review. The structure-activity relationship (SAR) was also given a lot of weight in this review in order to pinpoint the active pharmacophores of different indole analogues that have been the subject of studies for the past five years and are responsible for a variety of effects, including antiviral, antitubercular, anticancer, and anticonvulsant ones. The goals and framework of every research issue are explained in detail to help medicinal chemists have a deeper understanding of the circumstances contextually. Researchers will undoubtedly use this review as a platform to strategically design a variety of novel indole derivatives with lower toxicity and side effects and a range of intriguing pharmacological activity
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