Recent Advancement Of Oral And Topical Drug Release For Microsponges: A Comprehensive Review
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Abstract
Dermatological conditions greatly disrupt patients lives and have a profound emotional impact. Topical therapy is essential for the treatment of these conditions. Traditional topical delivery methods cause over- or under-medication, which has negative consequences and lowers the effectiveness of treatment. For which, numerous traditional and innovative carrier systems are available for topical treatment against different skin conditions. One of the more innovative carriers in recent times is microsponge technology. Basically microsponges are porous microsphere-based polymeric, tiny, globular particles with a sponge-like shape and a sizable porous surface. The control drug release of Microsponges are achieved by preparing them through liquid-liquid suspension polymerization, Quasi -emulsion solvent diffusion technique with a variety of different types of polymers like Ethylcellulose, ERS 100, EL100, ES100, EC etc. This paper offers a comprehensive explanation of the innovative state-of-the-art at this time, important factors affecting the mechanism and efficacy of drug release from topically applied microsponges, and characterization techniques. These formulations increased patient compliance by offering site-specific medication delivery and reduction in irritability, greater stability, and increased therapeutic efficacy.
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