Clinically Evaluating The Level Of Tumor Necrosis Factor-Alpha On Tissue Around Implant And Tooth
Main Article Content
Abstract
Background: Implant dentistry has become increasingly prevalent, with complications such as peri-implantitis posing challenges. Tumor necrosis factor-alpha (TNF-α) has been implicated in the inflammatory response around dental implants, akin to its role in periodontal diseases. Evaluating TNF-α levels in peri-implant tissues compared to healthy tooth tissues could provide insights into the inflammatory environment and aid in clinical management.
Materials and Methods: A cross-sectional study was conducted involving 50 participants with dental implants and healthy adjacent teeth. Peri-implant mucosal samples and gingival tissue around healthy teeth were collected. TNF-α levels were quantified using enzyme-linked immunosorbent assay (ELISA) kits. Statistical analysis was performed to compare TNF-α concentrations between peri-implant tissues and healthy tooth tissues.
Results: The mean TNF-α level in peri-implant tissues was found to be 120 pg/mL (standard deviation ± 25 pg/mL), whereas in healthy tooth tissues, it was 60 pg/mL (standard deviation ± 15 pg/mL). Statistical analysis revealed a significant difference (p < 0.05) in TNF-α levels between peri-implant tissues and healthy tooth tissues.
Conclusion: Elevated levels of TNF-α in peri-implant tissues suggest a heightened inflammatory response compared to healthy tooth tissues. This underscores the potential role of TNF-α in peri-implantitis pathogenesis and emphasizes the importance of monitoring inflammatory biomarkers for early detection and targeted intervention in implant dentistry.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Branemark PI, Hansson BO, Adell R, Breine U, Lindström J, Hallén O, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl. 1977;16:1-132.
Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015;42 Suppl 16:S158-71.
Mombelli A, Lang NP. The diagnosis and treatment of peri-implantitis. Periodontol 2000. 1998;17:63-76.
Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008;35(8 Suppl):282-5.
Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol. 2003;74(3):391-401.
Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 2007;7(4):292-304.
Mombelli A, Feloutzis A, Bragger U, Lang NP. Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results. Clin Oral Implants Res. 2001;12(4):287-94.
Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89 Suppl 1:S313-8.
Hani M, de-la-Pinta I, Grau D, García E, Sanz M. Tumor necrosis factor-alpha levels in the peri-implant sulcus of patients with peri-implantitis. J Clin Periodontol. 2012;39(7):726-33.