Exploring Phytotherapy For Alopecia: Efficacy, Mechanisms, And Future Directions

Main Article Content

Nasira Bano
Kuldip Kumar Savita
Vaibhav Srivastava
Khushboo Mishra

Abstract

Alopecia, a condition characterized by hair loss, affects a significant portion of the population and has various psychological and physical impacts. This review article explores the efficacy and safety of herbal treatments for alopecia, integrating traditional knowledge with contemporary scientific research. The article examines various herbal remedies used across cultures, such as Saw Palmetto, Ginseng, Green Tea, and Phyllanthus Emblica, delving into their bioactive compounds and mechanisms of action. Studies and case reports, adhering to APA citation style, highlight the potential of these natural remedies in promoting hair growth and managing different types of alopecia. The review also addresses the safety profile and toxicological considerations of these herbal treatments, underscoring the importance of comprehensive evaluations and standardized dosages. The integration of herbal treatments with conventional therapies is discussed as a promising avenue for enhancing treatment outcomes. The article concludes by emphasizing the need for more rigorous clinical trials, exploration of new herbal compounds, and the development of standardized, safe herbal formulations for alopecia treatment.

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How to Cite
Nasira Bano, Kuldip Kumar Savita, Vaibhav Srivastava, & Khushboo Mishra. (2024). Exploring Phytotherapy For Alopecia: Efficacy, Mechanisms, And Future Directions. Journal of Advanced Zoology, 45(3), 761–770. https://doi.org/10.53555/jaz.v45i3.4446
Section
Articles
Author Biographies

Nasira Bano

M. Pharm Research scholar, Smt. Vidyawati College of Pharmacy,
Gora Machhiya, Kanpur Road Jhansi U.P

Kuldip Kumar Savita

HOD, Smt. Vidyawati College of Pharmacy Jhansi U.P

Vaibhav Srivastava

Associate Professor, Smt. Vidyawati College of Pharmacy Jhansi U.P

Khushboo Mishra

Associate Professor, Smt. Vidyawati College of Pharmacy Jhansi U.P.

References

Asnaashari, S., &Javadzadeh, Y. (2020). Herbal medicines for treatment of androgenic alopecia. Alternative Therapies in Health and Medicine, 26(4), 27–35. https://www.ncbi.nlm.nih.gov/pubmed/31221945

Lueangarun, S., &Panchaprateep, R. (2020). An herbal extract combination (biochanin A, acetyl tetrapeptide-3, and ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia: A 24-week, prospective, randomized, triple-blind, controlled trial. The Journal of Clinical and Aesthetic Dermatology, 13(10), 32–37. https://www.ncbi.nlm.nih.gov/pubmed/33584955

Case Medical Research. (2020). Quality of life comparison in patients with different types of alopecia. Case Medical Research. https://doi.org/10.31525/ct1-nct04246957

Colombe, B. W., Price, V. H., Khoury, E. L., Garovoy, M. R., & Lou, C. D. (1995). HLA class II antigen associations help to define two types of alopecia areata. Journal of the American Academy of Dermatology, 33(5 Pt 1), 757–764. https://www.ncbi.nlm.nih.gov/pubmed/7593774

Hlail, A. T. (2020). Various types of Alopecia and the options of the treatment. AL-Kindy College Medical Journal, 16(2), 1–6. https://doi.org/10.47723/kcmj.v16i2.253

Ju, B. H., Choi, Y. K., Yu, S. A., & Lee, S. Y. (2013). A case report on child with different types of alopecia. The Journal of Pediatrics of Korean Medicine, 27(3), 53–64. https://doi.org/10.7778/jpkm.2013.27.3.053

Lin, J., Saknite, I., Valdebran, M., Balu, M., Lentsch, G., Williams, J. N., Koenig, K., Tromberg, B. J., &AtanaskovaMesinkovska, N. (2019). Feature characterization of scarring and non-scarring types of alopecia by multiphoton microscopy. Lasers in Surgery and Medicine, 51(1), 95–103. https://doi.org/10.1002/lsm.23017

Peter, D., George, L., &Pulimood, S. A. (2013). Trichoscopic features of various types of alopecia areata in India: application of a hand-held dermoscope. The Australasian Journal of Dermatology, 54(3), 198–200. https://doi.org/10.1111/j.1440-0960.2012.00942.x

Tojo, G., Fujimura, T., Kawano, M., Ogasawara, K., Kambayashi, Y., Furudate, S., Mizuashi, M., &Aiba, S. (2013). Comparison of interleukin-17- producing cells in different clinical types of alopecia areata. Dermatology (Basel, Switzerland), 227(1), 78–82. https://doi.org/10.1159/000353159

Vañó-Galván, S., Saceda-Corralo, D., Blume-Peytavi, U., Cucchía, J., Dlova, N. C., Gavazzoni Dias, M. F. R., Grimalt, R., Guzmán-Sánchez, D., Harries, M., Ho, A., Holmes, S., Larrondo, J., Mosam, A., Oliveira-Soares, R., Pinto, G. M., Piraccini, B. M., Pirmez, R., De la Rosa Carrillo, D., Rudnicka, L., … Miteva, M. (2019). Frequency of the types of alopecia at twenty-two specialist hair clinics: A multicenter study. Skin Appendage Disorders, 5(5), 309–315. https://doi.org/10.1159/000496708

Bajoria, P. S., Dave, P. A., Rohit, R. K., Tibrewal, C., Modi, N. S., Gandhi, S. K., & Patel, P. (2023). Comparing current therapeutic modalities of androgenic alopecia: A literature review of clinical trials. Cureus, 15(7), e42768. https://doi.org/10.7759/cureus.42768

Dobkin, H., Mullen, R., &Zirwas, M. (2019). Alopecia universalis and atopic dermatitis improvement with dupilumab: Demonstration of a shared pathophysiology and clinical efficacy. Skinmed, 17(2), 139–140. https://www.ncbi.nlm.nih.gov/pubmed/31145072

Fukuyama, M., Ito, T., & Ohyama, M. (2022). Alopecia areata: Current understanding of the pathophysiology and update on therapeutic approaches, featuring the Japanese Dermatological Association guidelines. The Journal of Dermatology, 49(1), 19–36. https://doi.org/10.1111/1346-8138.16207

Jabbari, A., Cerise, J., Chen, J. C., Sansaricq, F., Clynes, R., Christiano, A. M., & Mackay-Wiggan, J. (2017). 331 An open label clinical trial of the JAK inhibitor tofacitinib for alopecia areata. The Journal of Investigative Dermatology, 137(5), S56. https://doi.org/10.1016/j.jid.2017.02.347

Kinoshita-Ise, M., Foster, F. S., & Shear, N. H. (2019). Immune checkpoint inhibitor-related alopecia: Insight into the pathophysiology utilizing non-invasive diagnostic techniques. The Journal of Dermatology, 46(5), e152–e153. https://doi.org/10.1111/1346-8138.14736

Lintzeri, D. A., Constantinou, A., Hillmann, K., Ghoreschi, K., Vogt, A., & Blume-Peytavi, U. (2022). Alopecia areata - Current understanding and management. Journal Der DeutschenDermatologischen Gesellschaft [Journal of the German Society of Dermatology], 20(1), 59–90. https://doi.org/10.1111/ddg.14689

Lourenço, N., & Gonçalo, M. (2023). Alopecia areata: from pathophysiology to therapeutic innovation. Portuguese Journal of Dermatology and Venereology, 81(2). https://doi.org/10.24875/pjdv.23000014

Magro, C. M., Solomon, G. J., Kendrick, M. J. J., &Momtahen, S. (2019). Amyloid-associated alopecia: A reappraisal including its pathophysiology. The American Journal of Dermatopathology, 41(11), 799–806. https://doi.org/10.1097/DAD.0000000000001385

Paggioli, I., & Moss, J. (2022). Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors. Journal of Autoimmunity, 133(102926), 102926. https://doi.org/10.1016/j.jaut.2022.102926

snaashari, S., &Javadzadeh, Y. (2020). Herbal medicines for treatment of androgenic alopecia. Alternative Therapies in Health and Medicine, 26(4), 27–35. https://www.ncbi.nlm.nih.gov/pubmed/31221945

Khandagale, S. S., Ratnaparkhe, C. L., Sayyad, S. R., Shelar, V. D., Supekar, A. V., &Sarukh, V. S. (2023). A review of herbal medications for the treatment of alopecia. International Journal of Ayurveda and Pharma Research, 5–10. https://doi.org/10.47070/ijapr.v11isuppl4.2974

Pekmezci, E., Dündar, C., & Türkoğlu, M. (2018). A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study. Acta Dermatovenerologica Alpina, Panonica, et Adriatica, 27(2), 51–57. https://doi.org/10.15570/actaapa.2018.13

Yeniay, Y., & Arca, E. (2022). Evaluation of the efficacy and safety of topical procyanidin b2 and placebo in the treatment of androgenetic alopecia in men; A randomized, double-blind, placebo-controlled study. Turkish Journal of Dermatology / Türk DermatolojiDergisi, 16(4), 108. https://doi.org/10.4103/tjd.tjd_41_22

Bhusal, N., Ph.D. Scholar, Department of Panchakarma, National Institute of Ayurveda, Jaipur, Rajasthan-302002, India, Mangal, G., & Assistant Professor and Head, Department of Panchakarma, National Institute of Ayurveda, Jaipur, Rajasthan302002, India. (2017). Management of alopecia by bloodletting and certain Ayurveda medicine: A case study. Journal of Ayurvedic and Herbal Medicine, 3(3), 108–110. https://doi.org/10.31254/jahm.2017.3301

Kim, J.-S., & Park, S.-Y. (2016). A Case of Alopecia areata treated with Korean Medical Treatment. Herbal Formula Science, 24(2), 124–130. https://doi.org/10.14374/hfs.2016.24.2.124

Chaudhary, S., V., Bhaskar, C. L., Patel, K. S., Kori, V. K., (2019). Alopecia Areata (Khalitya) in Children: Ayurvedic Management. Journal of Ayurvedic and Herbal Medicine, 5(2), 35–40. https://doi.org/10.31254/jahm.2019.5201

Lotfi, E., Aramianpour, N., & Salehi, B. (2022). Combination of platelet-rich plasma and platelet gel in treatment of resistance androgenic alopecia: A case series study. Journal of Cosmetic Dermatology, 21(10), 4307–4312. https://doi.org/10.1111/jocd.14963

Ju, B. H., Choi, Y. K., Yu, S. A., & Lee, S. Y. (2013). A case report on a child with different types of alopecia. The Journal of Pediatrics of Korean Medicine, 27(3), 53–64. https://doi.org/10.7778/jpkm.2013.27.3.053

HwangBo, M., Jeong, M.-J., & Seo, H.-S. (2012). A case report of a child with alopecia areata. The Journal of Pediatrics of Korean Medicine, 26(2), 47–52. https://doi.org/10.7778/jpkm.2012.26.2.047

Himmelreich, F., Jetter, A., Kiessling, M. K., Kadvany, Y., & Trojan, A. (2023). Interference of herbal medicine with axitinib in metastatic renal cell cancer treatment: A case study. Case Reports in Oncology, 16(1), 1362–1369. https://doi.org/10.1159/000534595

Kwon, O. S., Han, J. H., Yoo, H. G., Chung, J. H., Cho, K. H., Eun, H. C., & Kim, K. H. (2007). Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine, 14(7-8), 551–555. https://doi.org/10.1016/j.phymed.2006.09.009

Murata, K., Noguchi, K., Kondo, M., Onishi, M., Watanabe, N., Okamura, K., & Matsuda, H. (2015). Promotion of hair growth by Rosmarinus officinalis leaf extract. Phytotherapy Research, 29(2), 212–217. https://doi.org/10.1002/ptr.5260

Prager, N., Bickett, K., French, N., & Marcovici, G. (2002). A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. Journal of Alternative and Complementary Medicine, 8(2), 143–152. https://doi.org/10.1089/107555302317371433

Yu, J. Y., Gupta, B., Park, H. G., Yadav, V. K., Baek, S. Y., & Choi, D. Y. (2005). Preclinical and clinical studies demonstrate that the proprietary herbal extract DA-5512 effectively stimulates hair growth and promotes hair health. Evidence-Based Complementary and Alternative Medicine, 2017, 4395638. https://doi.org/10.1155/2017/4395638

Agbabiaka, T. B., Pittler, M. H., Wider, B., & Ernst, E. (2009). Serenoa repens (Saw Palmetto): a systematic review of adverse events. Drug Safety, 32(8), 637–647. https://doi.org/10.2165/00002018-200932080-00003

Panahi, Y., Taghizadeh, M., Marzony, E. T., &Sahebkar, A. (2015). Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed, 13(1), 15–21. https://www.ncbi.nlm.nih.gov/pubmed/25842469

Sarma, D. N., Barrett, M. L., Chavez, M. L., Gardiner, P., Ko, R., Mahady, G. B., Marles, R. J., Pellicore, L. S., Giancaspro, G. I., & Low Dog, T. (2008). Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Safety, 31(6), 469–484. https://doi.org/10.2165/00002018-200831060-00003

Wang, C. Z., Anderson, S., Du, W., He, T. C., & Yuan, C. S. (2015). Red ginseng and cancer treatment. Chinese Journal of Natural Medicines, 13(1), 3–15. https://doi.org/10.1016/S1875-5364(15)60002-9

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