Development And Characterization Of Colon Targeted Microspheres For Intestinal Infection
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Abstract
Various colon-targeted oral delivery systems have been explored so far to treat colorectal diseases, including timed-release systems, prodrugs, pH-based polymer coatings, and microflora-triggered systems. The polysaccharide-based colon-targeted delivery system has been found to be quite promising as polysaccharides remain unaffected by gastric as well as upper intestine milieu and are only digested by colonic bacteria upon reaching the colon. The metronidazole containing microsphere has other characterization is in the term of percentage yield, entrapment efficiency, FT-IR and the in-vitro drug release. The In-vitro release pattern of metronidazole studied in colonic environment as 900ml media using USP dissolution apparatus II. The cumulative release rate of prepared microspheres was followed by a sustained release and fitted for classic Higuchi kinetic model. The results showed that chitosan microspheres are thought to have the potential to maintain drug concentration within target ranges for a long time, decreasing side effects caused by concentration fluctuation, ensuring the efficiency of treatment and improving patient compliance by reducing dosing frequency.
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