Exploring the Versatility of Topical Gels: - An Overview

Main Article Content

Rohit Keshav Dimote
Avesh Aslam Tamboli
Shendge Roasaheb S

Abstract

Topical gels represent semi-solid formulations characterized by a phase of matter existence that is fluid encased within A three-dimensional structure made of polymers, typically consisting of synthetic or natural gums with substantial cross-linking, achieved either chemically or physically. Their unique composition enables diverse applications owing to their intermediate state between liquid and solid phases. In recent times, topical gels have garnered significant interest across various sectors, including industry, research, education, drug regulation, and professional fields. Special emphasis is placed on the utilization of gels in drug delivery systems; the discussion serves to provide insights into the versatility and involving landscape of topical gels, catering to the interests and needs of professionals and researchers in diverse domains.

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How to Cite
Rohit Keshav Dimote, Avesh Aslam Tamboli, & Shendge Roasaheb S. (2024). Exploring the Versatility of Topical Gels: - An Overview. Journal of Advanced Zoology, 45(3), 644–654. https://doi.org/10.53555/jaz.v45i3.4366
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Articles
Author Biographies

Rohit Keshav Dimote

Research Scholar, Department Of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon (Autonomous) , Maharashtra, India 423603

Avesh Aslam Tamboli

Research Scholar, Department Of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, (Autonomous) Maharashtra, India 423603

Shendge Roasaheb S

Professor, Department Of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, (Autonomous) Maharashtra, India 423603

References

(1) Tadwee, I. K.; Gore, S.; Giradkar, P. Advances in Topical Drug Delivery System: A Review.

(2) Singh, V.; Singh, P.; Sharma, P.; Srivastava, P.; Mishra, A. FORMULATION AND EVALUATION OF TOPICAL GEL OF ACELOFENAC CONTAINING PIPARINE. Indo Am. J. Pharm. Res. 2231-6876 2013, 20133.

(3) Rathod, H.; Mehta, D. A Review on Pharmaceutical Gel. Int. J. Pharm. Sci. 2015, 1, 33–47.

(4) Publishers, C. B. S. PHARMACEUTICAL PRODUCT DEVELOPMENT 3ED (HB 2018) . Default Store View. https://www.cbspd.co.in/pharmaceutical-product-development-3ed-hb-2018-9789386827562-jain-n-k (accessed 2024-03-12) .

(5) Murdan, S. Organogels in Drug Delivery. Expert Opin. Drug Deliv. 2005, 2 (3) , 489–505. https://doi.org/10.1517/17425247.2.3.489.

(6) Vintiloiu, A.; Leroux, J.-C. Organogels and Their Use in Drug Delivery--a Review. J. Control. Release Off. J. Control. Release Soc. 2008, 125 (3) , 179–192. https://doi.org/10.1016/j.jconrel.2007.09.014.

(7) Harper D. Gel. Wikipedia; 2024.

(8) Al-Khashab, Y. E. N.; Hummadi, Y. M. K. A.-M.; Hamadi, S. A.; Al-Waiz, M. M. Formulation and Evaluation of Ciprofloxacin as a Topical Gel. Al Mustansiriyah J. Pharm. Sci. 2010, 8 (2) , 80–95. https://doi.org/10.32947/ajps.v8i2.341.

(9) Scheindlin, S. Transdermal Drug Delivery: PAST, PRESENT, FUTURE. Mol. Interv. 2004, 4 (6) , 308–312. https://doi.org/10.1124/mi.4.6.1.

(10) Chopda, G. Transdermal Drug Delivery Systems : A Review. Pharm. Rev. 2006.

(11) Basha, B. N.; Prakasam, K.; Goli, D. Formulation and Evaluation of Gel Containing Fluconazole-Antifungal Agent. 2011.

(12) Florence a. t., Attwood d. - Physicochemical Principles of Pharmacy (4th Edition) (2006) (492s) .Pdf. http://library.navoiy-uni.uz/files/florence%20a.%20t.,%20attwood%20d.%20-%20physicochemical%20principles%20of%20pharmacy%20(4th%20edition) (2006) (492s) .pdf (accessed 2024-03-12) .

(13) Cooper and Gunn. Disperse Systems. In: Carter SJ, Editor. Tutorial Pharmacy. CBS Publ. Distrib. 2000, 68–72.

(14) Shelke, S. J.; Shinkar, D.; Saudagar, R. Topical Gel: A Novel Approach for Development of Topical Drug Delivery System. Int. J. Pharm. Technol. 2013, 5, 2739–2763.

(15) Allen, L. V.; Popovich, N. G.; Ansel, H. C. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems.

(16) Nabi, S. A. A. un; Sheraz, M. A.; Ahmed, S.; Mustaan, N.; Ahmad, I. Pharmaceutical Gels: A Review. RADS J. Pharm. Pharm. Sci. 2016, 4 (1) , 40–48.

(17) B, S. A.; Jeganath, S.; Jeevitha, E. Pharmaceutical Gels and Recent Trends –A Review. Res. J. Pharm. Technol. 2019, 12 (12) , 6181–6186. https://doi.org/10.5958/0974-360X.2019.01073.4.

(18) Karande, P.; Mitragotri, S. Enhancement of Transdermal Drug Delivery via Synergistic Action of Chemicals. Biochim. Biophys. Acta BBA - Biomembr. 2009, 1788 (11) , 2362–2373. https://doi.org/10.1016/j.bbamem.2009.08.015.

(19) E01_978-0-12-817909-3_01.Pdf. https://toc.library.ethz.ch/objects/pdf03/e01_978-0-12-817909-3_01.pdf (accessed 2024-03-12) .

(20) Klein, M.; Poverenov, E. Natural Biopolymer‐based Hydrogels for Use in Food and Agriculture. J. Sci. Food Agric. 2020, 100 (6) , 2337–2347. https://doi.org/10.1002/jsfa.10274.

(21) Patil, A.; Ferritto, M. S. Polymers for Personal Care and Cosmetics: Overview. In ACS Symposium Series; Patil, A., Ferritto, M. S., Eds.; American Chemical Society: Washington, DC, 2013; Vol. 1148, pp 3–11. https://doi.org/10.1021/bk-2013-1148.ch001.

(22) Robert Y. Lochhead. The Role of Polymers in Cosmetics: Recent Trends. https://www.researchgate.net/publication/283769247_The_Role_of_Polymers_in_Cosmetics_Recent_Trends (accessed 2024-03-12) .

(23) (Gajre) Kulkarni, V.; Butte, K.; Rathod, S. Natural Polymers- A Comprehensive Review. Int. J. Res. Pharm. Biomed. Sci. 2012, 3, 1597–1613.

(24) Alonso-Sande, M.; Teijeiro-Osorio, D.; Remuñán-López, C.; Alonso, M. J. Glucomannan, a Promising Polysaccharide for Biopharmaceutical Purposes. Eur. J. Pharm. Biopharm. 2009, 72 (2) ,453–462. https://doi.org/10.1016/j.ejpb.2008.02.005.

(25) Hamman, J. H. Composition and Applications of Aloe Vera Leaf Gel. Molecules 2008, 13 (8) , 1599–1616. https://doi.org/10.3390/molecules13081599.

(26) Ahad, H. A.; Kumar, C. S. Development and in Vitro Evaluation of Glibenclamide Aloe Barbadensis Miller Leaves Mucilage Controlled Release Matrix Tablets.

(27) K, L.; S, B.; V, V.; N, D.; H, von B.; D, S. Optimization of the Preparation Process for Human Serum Albumin (HSA) Nanoparticles. Int. J. Pharm. 2003, 257 (1–2) . https://doi.org/10.1016/s0378-5173(03) 00134-0.

(28) Suhail, M.; Hsieh, Y.-H.; Khan, A.; Minhas, M. U.; Wu, P.-C. Preparation and In Vitro Evaluation of Aspartic/Alginic Acid Based Semi-Interpenetrating Network Hydrogels for Controlled Release of Ibuprofen. Gels 2021, 7 (2) , 68. https://doi.org/10.3390/gels7020068.

(29) Nomenclature and Symbolism for Amino Acids and Peptides: Recommendations 1983. Eur. J. Biochem. 1984, 138 (1) , 9–37. https://doi.org/10.1111/j.1432-1033.1984.tb07877.x.

(30) Demchenko, V.; Rybalchenko, N.; Zahorodnia, S.; Naumenko, K.; Riabov, S.; Kobylinskyi, S.; Vashchuk, A.; Mamunya, Y.; Iurzhenko, M.; Demchenko, O.; Adamus, G.; Kowalczuk, M. Preparation, Characterization, and Antimicrobial and Antiviral Properties of Silver-Containing Nanocomposites Based on Polylactic Acid-Chitosan. ACS Appl. Bio Mater. 2022, 5 (6) , 2576–2585. https://doi.org/10.1021/acsabm.2c00034.

(31) Lev R, Long R, Mallonga L, Schnaram R and Reily W. Evaluation of Carrageenan as Base for Topical Gels. Pharm Res 1997.

(32) Kadajji, V. G.; Betageri, G. V. Water Soluble Polymers for Pharmaceutical Applications. Polymers 2011, 3 (4) , 1972–2009. https://doi.org/10.3390/polym3041972.

(33) Abdul Khalil, H. P. S.; Tye, Y. Y.; Saurabh, C. K.; Leh, C. P.; Lai, T. K.; Chong, E. W. N.; Nurul Fazita, M. R.; Mohd Hafiidz, J.; Banerjee, A.; Syakir, M. I. Biodegradable Polymer Films from Seaweed Polysaccharides: A Review on Cellulose as a Reinforcement Material. Express Polym. Lett. 2017, 11 (4) , 244–265. https://doi.org/10.3144/expresspolymlett.2017.26.

(34) Van Tomme, S. R.; Van Nostrum, C. F.; De Smedt, S. C.; Hennink, W. E. Degradation Behavior of Dextran Hydrogels Composed of Positively and Negatively Charged Microspheres. Biomaterials 2006, 27 (22) , 4141–4148. https://doi.org/10.1016/j.biomaterials.2006.03.023.

(35) de Jong, S. J.; De Smedt, S. C.; Demeester, J.; van Nostrum, C. F.; Kettenes-van den Bosch, J. J.; Hennink, W. E. Biodegradable Hydrogels Based on Stereocomplex Formation between Lactic Acid Oligomers Grafted to Dextran. J. Control. Release Off. J. Control. Release Soc. 2001, 72 (1–3) , 47–56. https://doi.org/10.1016/s0168-3659(01) 00261-9.

(36) Jantrawut, P.; Ruksiriwanich, W. Carbopol®-Guar Gum Gel as a Vehicle for Topical Gel Formulation of Pectin Beads Loaded with Rutin. Asian J. Pharm. Clin. Res. 2014, 7, 231–236.

(37) Hathout, R. M.; Metwally, A. A. Gelatin Nanoparticles. Methods Mol. Biol. Clifton NJ 2019, 2000, 71–78. https://doi.org/10.1007/978-1-4939-9516-5_6.

(38) Cosgrove, D. J. Growth of the Plant Cell Wall. Nat. Rev. Mol. Cell Biol. 2005, 6 (11) , 850–861. https://doi.org/10.1038/nrm1746.

(39) Ying, H.; Zhou, J.; Wang, M.; Su, D.; Ma, Q.; Lv, G.; Chen, J. In Situ Formed Collagen-Hyaluronic Acid Hydrogel as Biomimetic Dressing for Promoting Spontaneous Wound Healing. Mater. Sci. Eng. C Mater. Biol. Appl. 2019, 101, 487–498. https://doi.org/10.1016/j.msec.2019.03.093.

(40) Kwon, M. Y.; Wang, C.; Galarraga, J. H.; Puré, E.; Han, L.; Burdick, J. A. Influence of Hyaluronic Acid Modification on CD44 Binding towards the Design of Hydrogel Biomaterials. Biomaterials 2019, 222, 119451. https://doi.org/10.1016/j.biomaterials.2019.119451.

(41) Learn How Voltaren Emulgel Can Help You Relieve Pain. https://www.voltaren.com.au/products/pain-relief-gel/voltaren-triple-effect-emulgel/ (accessed 2024-03-13) .

(42) Ch, S. K. DICLOMAX POWER GEL ( TORRENT PHARMACEUTICALS LTD ) - Buy DICLOMAX POWE. https://www.medplusmart.com/product/diclomax-power-gel_dicl0049 (accessed 2024-03-13) .

(43) MICONAZ H GEL - Gardenia Pharmacy. https://gardeniapharmacies.com/product/miconaz-h-gel/?lang=en (accessed 2024-03-13) .

(44) Emulgel Derma Feet Urea 40%. https://herbitas.com/en/emulgel-derma-feet-urea-40-cream.html (accessed 2024-03-13) .

(45) Isofen – Beit Jala Pharma. https://beitjalapharma.com/product/isofen/ (accessed 2024-03-13) .

(46) Kuwait Saudi Pharmaceutical Industries Company. https://kspico.com/diclona-emulgel.html (accessed 2024-03-13) .

(47) Dosanac Full Prescribing Information, Dosage & Side Effects | MIMS Singapore. https://www.mims.com/singapore/drug/info/dosanac?type=full (accessed 2024-03-13) .

(48) Diclon Gel 30gm. indiamart.com. https://www.indiamart.com/proddetail/diclon-gel-30gm-2852722107730.html (accessed 2024-03-13) .

(49) Denacine – Beit Jala Pharma. https://beitjalapharma.com/product/denacine/ (accessed 2024-03-13) .

(50) TNMEDS.com. Avindo gel 20g Online, View Uses of Avindo gel 20g, Review of Avindo gel 20g, Composition | TNMEDS. https://www.tnmeds.com/avindo-gel-20g-28647.html (accessed 2024-03-13) .