Therapeutic Potential Of Bacopa Monnieri Against Alcohol Induced Cardiac Toxicity In Rats
Main Article Content
Abstract
A study was conducted to investigate the potential protective effects of Bacopa monnieri extract on alcohol-induced toxicity in rats, focusing on its hypolipidemic and cardioprotective properties. For a period of 30 days, the experimental rats were orally intoxicated with alcohol (2 g/kg body weight) daily. Simultaneously, Bacopa monnieri extract was administered at a dose of 200 mg/kg body weight. The results of the study revealed that the rats subjected to alcohol-induced toxicity experienced a significant reduction in antioxidant defense systems, such as reduced glutathione (GSH) and ascorbic acid, while the activity of glutathione-S-transferase was enhanced compared to the control group. Additionally, the alcohol-induced group exhibited increased levels of triglycerides (TG) and total cholesterol (TC), as well as a significant decrease in phospholipids (PL). However, when Bacopa monnieri was supplemented along with alcohol, it significantly improved the antioxidant status and normalized the lipid profiles. These findings suggest that Bacopa monnieri possesses cardioprotective and hypolipidemic activities, which provide protection against alcohol-induced toxicity.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Walldius G, Jungner I (2006). The apoB/apoA-I ratio: a Strong, new risk factors for cardiovascular disease and target for lipid-lowering therapy: a review of the evidence. J Intern Med. 259:493–519.
Ye L., Pan Y., Zheng W., Hu J (2019). miR-186-5p is Expressed Highly in Ethanol-induced Cardiomyocytes and Regulates Apoptosis by Target Gene XIAP. China Biotechnol. 39:53–62.
Arulmozhi V, Krishnaveni M, Karthishwaran K, Dhamodharan G, Mirunalini, S (2010). Antioxidant and antihyperlipidemic effect of Solanum nigrum fruit extract on the experimental model against chronic ethanol toxicity, Phcog. Mag., 6: 42-50.
Mallikarjuna K., Shanmugam K.R., Nishanth K., Wu M.-C., Hou C.-W., Kuo C.-H., Reddy K.S. (2010). Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats. Alcohol. 44:523–529.
Lieber., C.S., Mt. Sinai, (2000). J. Med., 67, 84-94.
Semenkovich, CF, Goldberg AC, Goldberg, IJ. Chapter 137. (2011). Disorders of lipid metabolism. In: MelmedS, Polonsky KS, Larsen PR, Kronberg HM, editors. Williams Textbook of Endocrinology. 12thEd.NewDelhi: Elsevier;1633-1674
Zhou Z, Sun X, Kang JY. (2003). Methionine protection against alcohol liver injury through inhibition of oxidative stress. Exp Biol Med, 222:214-22.
Kode A, Rajagopalan R, Penumathsa S V & Menon V P, 2004. Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil-induced oxidative stress, Fund Clin Pharmacol,18, 565.
Rodrigo R, Trujillo S, Bosco C, Orellana M, Thielemann L & Araya J, (2002). Changes in (Na+K)-adenosine triphosphatase activity and ultra-structure of lung and kidney associated with oxidative stress induced by acute ethanol intoxication, Chest, 121, 589.
Bilanda DC, Dimo T, Djomeni PD, Bella NM, Aboubakar OB, Nguelefack TB, (2010). Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. (Clusiaceae) aqueous extract in alcohol‑ and sucrose‑induced hypertensive rats. J Ethnopharmacol 128:634‑40.
Ahmed R S, Seth V & Banerjee B D, (2000). Influence of dietary ginger (Zingiber officinale Rosc) on antioxidant defence system in rat: Comparison with ascorbic acid, Indian J Exp Biol, 38, 604.
Dinu D, Nechifor MT, & Movileanu L (2005). Ethanol-induced alterations of the antioxidant defense system in rat kidney, J Biochem Mol Toxicol, 19, 386
Das S K & Vasudevan D M (2005). Effect of ethanol on liver antioxidant defence system: A dose dependent study, Indian J Clin Biochem, 20, 80.
Balasubramanian V, Kalaivani Sailaja J & Nalini N, (2003). Role of leptin on alcohol- induced oxidative stress in Swiss mice, Pharmacology Res, 47, 211.
Kumar, R. S, Ponmozhi, M., V. Periyasamy, V., and N. Namasivayam, N (2002). Asia Pac. J. Clin. Nutr., 11, 157163.
Yao Y.S., Li T.D., Zeng Z.H (2020). Mechanisms underlying direct actions of Hyperlipidemia on myocardium: An updated review. Lipids Health Dis. 19:23.
Thoen RU, Longo L, Leonhardt LC, Pereira MHM, Rampe lotto PH, Cerski CTS, et al (2023). Alcoholic liver disease and intestinal microbiota in an experimental model: biochemical, inflammatory, and histologic parameters. Nutrition. 106:111888.
Kim JW, Lee DY, Lee BC, Jung MH, Kim H, Choi YS, et al. (2012). Alcohol and cognition in the elderly: a review. Psychiatry Investig. 9(1):8-16.
Liu N, Huo G, Zhang L, Zhang Y, (2003). Effect of Zingiber officinal Rose on lipid peroxidation in hyperlipidaemia rats. Wei Shang Yan Jiu,32:22-3.