Herbal Aqueous Extract Used For Treatment Of Diabetes Mellitus (Type-2).

Main Article Content

Nitin Prajapati
Nadim Chhipa
Pragnesh Patani

Abstract

Diabetes is a lifelong (chronic) disease and is a group of metabolic disorders characterized by a high level of sugar in the blood [Hyperglycemia]. It is caused due to deficiency of insulin (diabetes insipidus) or resistance to insulin (diabetes mellitus). Insulin is secreted by β-cells of the pancreas to control blood sugar level. Both diabetes insipidus and diabetes mellitus can be treated with a variety of herbal plants, such as Tinospora cordifolia, Withania somnifera, Momordica charantia, Cinnamomum zeylanicum, Allium sativum, Panax ginseng, Gymnema sylvestre, Trigonella foenum graecum, and Azadirachta indica. Each of these medicinal plants has an anti-diabetic action, and their aqueous extracts are used to treat diabetes

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How to Cite
Nitin Prajapati, Nadim Chhipa, & Pragnesh Patani. (2024). Herbal Aqueous Extract Used For Treatment Of Diabetes Mellitus (Type-2). Journal of Advanced Zoology, 45(1), 463–472. https://doi.org/10.53555/jaz.v45i1.4242
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Articles
Author Biographies

Nitin Prajapati

Department of Pharmacy, Khyati College of Pharmacy, Palodia, Ahmedabad.

Nadim Chhipa

Associate Professor, Department of Pharmaceutical Chemistry, Khyati College of Pharmacy, Palodia, Ahmedabad

Pragnesh Patani

Principal and Professor, Department of Pharmacology, Khyati College of Pharmacy, Palodia, Ahmedabad

References

N Singh, R Kesherwani, AK Tiwari and DK Patel; A review on diabetes mellitus; The Pharma Innovation Journal; 5(7); 2016; 36-40.

A Ismail and S Ali; A review of diabetes mellitus and its complications; world journal of pharmaceutical and medical research; 8(6); 2022; 239-241.

A A Jan, A Khan, S Khan, M Khan; Causes, Complications and Management of Diabetes Mellitus; Chronicle Journal of Food and Nutrition; 1(1); 2017; 1-3.

Mayo Clinic.USA. Type 2 Diabetes: Disease and Condition. https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/symptoms-causes/syc-20351193 Accessed on 21 Aug. 23

Goyal R, Jialal I. Diabetes Mellitus Type 2. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2022. https://europepmc.org/article/nbk/nbk513253#impact Accessed on 21 August 2023.

P Srivastava; Study of medicinal properties of Herb Tinospora Cordifolia (Giloy) in preventing various diseases/abnormalities by increasing immunity naturally in human bodies; International Journal of Engineering Research and General Science; 8(4); 2020; 10-14.

C Saxena and G Rawat; Tinospora cordifolia (Giloy) - Therapeutic Uses and Importance: A review; Current Research in Pharmaceutical Sciences; 9(3); 2019; 42-45.

Sudha P, Zinjarde SS, Bhargava SY, Kumar AR. Potent α-amalyase inhibitory activity of Indian Ayurvedic Medicinal Plants. BMC Complementary and Alternative Medicine; 11(5); 2011; 1-10.

G R Rout; Identification of Tinospora cordifolia (Willd.) Miers ex Hook F. & Thomas Using RAPD Markers; Zeitschrift für Naturforschung C; 61; 2006; 118-122.

Promila, S Singh and P Devi; Pharmacological potential of Tinospora cordifolia (Willd.) Miers ex hook. & Thoms. (Giloy): A review; Journal of Pharmacognosy and Phytochemistry; 6(6); 2017; 1644-1647.

S Ayurveda; GILOY– A REVIEW; International Journal of Current Research; 13(1); 2021; 15779-15785.

A Singh, N A Bhatt, A Sagar, A Kumar, A Goswami; MEDICINAL USES OF GILOY: A REVIEW; European Journal of Molecular & Clinical Medicine; 8(4); 2021; 728-733.

B Joseph, D Jini; Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency; Asian Pacific Journal of Tropical Disease; 3(2); 2013; : 93-102.

R Chanda, A Samadder and J Banerjee; anti-diabetic Activity of Momordica Charantia or Bitter Melon: A Review; Acta Scientific Pharmaceutical Sciences; 3(5); 2019; 24-30.

M B Krawinkel and G B Keding; Bitter Gourd (Momordica charantia): A Dietary Approach to Hyperglycemia; Nutrition Reviews; 64(7); 2006; 331–337.

Welihinda J, Karunanayake EH, Sheriff MH, Jayasinghe KS; Effect of Momordica charantia on the glucose tolerance in type 2 diabetes; Journal of Ethnopharmacol; 17; 2006; 277-282.

K Abascal and E Yarnell; Using Bitter Melon to Treat Diabetes; Alternative & complementary therapies; 11(4); 2005; 179-184.

A Ahmad, S SAlghamdi, K Mahmood, M Afzal; Fenugreek a multipurpose crop: Potentialities and improvements; Saudi Journal of Biological Sciences; 23(2); 2016; 300-310.

JN Shashikumar, PS Champawat, VD Mudgal and SK Jain; Role of fenugreek (Trigonella foenum graecum) on in management of diabetes disease; Journal of Pharmacognosy and Phytochemistry; 8(4); 2019; 184-187.

M C Navarrete, K G Pérez-Rubio and M de J. Escobedo-Gutiérrez; Role of Fenugreek, Cinnamon, Curcuma longa, Berberine and Momordica charantia in Type 2 Diabetes Mellitus Treatment: A Review; Pharmaceuticals; 16(4); 2023; 1-23.

N Verma, K Usman, N Patel, A Jain, S Dhakre, A Swaroop, M Bagchi, P Kumar, H G. Preuss & D Bagchi; A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes; Food & Nutrition Research; 60; 2016; 1-8.

S Vyas; Effect of fenugreek (Methi dana) on carbohydrate and protein metabolism in diabetic patients; International Journal of Home Science; 9(1); 2023; 261-263.

A H Rahmani, A Almatroudi, F Alrumaihi, A A Khan; Pharmacological and Therapeutic Potential of Neem (Azadirachta indica); Pharmacognosy Reviews; 12(24); 2018; 250-255.

U Pingali, M A Ali, S Gundagani and C Nutalapati; Evaluation of the Effect of an Aqueous Extract of Azadirachta indica (Neem) Leaves and Twigs on Glycemic Control, Endothelial Dysfunction and Systemic Inflammation in Subjects with Type 2 Diabetes Mellitus – A Randomized, Double-Blind, Placebo-Controlled Clinical Study; Diabetes, Metabolic Syndrome and Obesity; 13; 2020; 4401-4412.

H A Asghar, S Abbas, M K Arshad, A Jabin, B Usman, M Aslam, A Asghar; Therapeutic Potential of Azadirachta indica (Neem)-A Comprehensive Review; cholars International Journal of Traditional and Complementary Medicine; 5(3): 47-64.

P R Novitasari, B M Gemantari, S Mufidah , P A Sari; Potential Effects of Neem Plants (Azadirachta indica A. Juss.) as an Antidiabetic Agent; journal of food and pharmaceutical science;9(2);2021; 422-430.

J C Pagadala, D Madduru, A S Tadepalli; A review on gymnema sylvestre a major antidiabetic asclepiadaceae herb; World Journal of Pharmaceutical Research; 4(8); 2015; 2724-2732.

S Laha, S Paul; Gymnema sylvestre (Gurmar): A Potent Herb with Anti-Diabetic and Antioxidant Potential; Pharmacognosy Journal; 11(2); 2019; 201-206.

A ota and N P Ulrih; An overview of herbal products and secondary metabolites used for management of type two diabetes; frontiers in pharmacology; 8; 2017; 1-14.

S Laha, S Paul; Gymnema sylvestre (Gurmar): A Potent Herb with Anti-Diabetic and Antioxidant Potential; Pharmacognosy Journal; 11(2); 2019; 201-206.

S Devangan, B Varghese, E Johny, S Gurram, R Adela; The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis; Phytotherapy Research; 35(12); 2021; 1-11.

G Gupta and A. C. Rana; Withania somnifera (Ashwagandha): A Review; Pharmacognosy Reviews; 1(1); 2007; 129-136.

M. Elsakka, E. Grigorescu, U. Stanescu, U. Stanescu, V. Dorneanu; New data referring to chemistry of Withania somnifera species; Revista Medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi; 94(2); 1990; 385-387.

S Nayak, S Nayak, B Panda, S Das; a clinical study on management of stress in type-2 diabetes mellitus (madhumeha) with ashwagandha (withania somnifera); An International Journal of Research in AYUSH and Allied Systems; 2(6); 2015; 413-417.

V Kumar, A Dey, and S S Chatterjee; Phytopharmacology of Ashwagandha as an Anti-Diabetic Herb; Springer International Publishing; 2017; 37-68.

Usharani, N Fatima, C Kumar, P.V. Kishan; evaluation of a highly standardized withania somnifera extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double blind, placebo controlled study; International Journal of Ayurveda and Pharma Research; 2(3); 2014; 22-32.

H Ram, A Krishna; Improvements in Insulin Resistance and β-Cells Dysfunction by DDP-4 Inhibition Potential of Withania somnifera (L.) Dunal Root Extract in Type 2 Diabetic Rat; platinum open access journal; 11(1); 2021; 8141–8155.

P V Rao and S H Gan; Cinnamon: A Multifaceted Medicinal Plant; Hindawi Publishing Corporation; 2014; 2014; 1-12.

B Qin, M Nagasaki, M Ren, G Bajotto, Y Oshida, Y Sato; Cinnamon extract (traditional herb) potentiates in vivo insulinregulated glucose utilization via enhancing insulin signaling in rats; Diabetes Research and Clinical Practice; 62; 2013; 139-148.

Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TPA; Indian herbs and herbal drugs used for the treatment of diabetes; J Clin Biochem Nutr; 40; 2007; 163–173.

R W Allen, E Schwartzman, W L Baker, Craig I. Coleman,Olivia J. Phung; Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis; annals of family medicine; 11(5); 2013; 452-459.

R Akilen, A Tsiami, D Devendra,N Robinson; Cinnamon in glycaemic control: Systematic review and meta analysis; Clinical Nutrition; 31; 2012; 609-615.

W Chen, P Balan, D G Popovich; Review of Ginseng Anti-Diabetic Studies; Molecules; 24(24); 2019; 1-16.

W Chen, P Balanb, D G Popovicha; Comparison of the ginsenoside composition of Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L.) and their transformation pathways; Studies in Natural Products Chemistry; 63; 2019; 161-195.

H D Yuan, J T Kim, S H Kim, S H Chung; Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies; Journal of ginseng research; 34(1); 2012; 27-39.

J T Xie, S Mehendale, C Yuan; Ginseng and Diabetes; The American Journal of Chinese Medicine; 33(3); 2005; 397–404.

Q Gui, Z Xu, K Xu, Y M Yang; The Efficacy of Ginseng-Related Therapies in Type 2 Diabetes Mellitus; Medicine; 95(6); 2016; 1-10.

V Vuksan, J L. Sievenpiper; Herbal remedies in the management of diabetes: Lessons learned from the study of ginseng; Nutrition, Metabolism & Cardiovascular Diseases; 15; 2005; 149-160.

R Padiya and S K. Banerjee; Garlic as an Anti-diabetic Agent: Recent Progress and Patent Reviews; Recent Patents on Food, Nutrition & Agriculture; 5(1); 2013; 1-23.

S. K. Banerjee, P K. Mukherjee, S. K. Maulik; Garlic as an Antioxidant: The Good, the Bad and The Ugly; phytotherapy research; 17; 2003; 97–106.

A Jahromi, Z Zia, M Afarid; A review on the efect of garlic on diabetes, BDNF, and VEGF as a potential treatment for diabetic retinopathy; Sanie Jahromi et al. Chinese Medicine; 18(18); 2023; 1-14.

RA M. Phil, R Khan, I Ashraf; Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus; Journal of Medicinal Plants Research; 5(13); 2011; 2922-2928.

C Liu, L Sheen, C Lii; Does garlic have a role as an antidiabetic agent?; molecular nutrition food and research; 51(11); 2007; 1353 – 1364.

J Wang, X Zhang, H Lan and W Wang; Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials; Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials; 61(1); 2017; 1-9.

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