Phyto-Pharmacology Profile Of Holarrhena Antidysenterica: A Review

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Manthan M. Thawkar
Maroti M. Jeurkar
Mohit G. Saktel
Satish P. Mohitkar

Abstract

Medicinal plants have been recognized for centuries and are highly regarded worldwide as a valuable source of therapeutic agents for disease prevention and treatment. Holarrhena antidysenterica, commonly known as kauri, kurchi, or kutaj, has been employed since ancient times. Holarrhena antidysenterica (also known as H. pubescens), a member of the Apocynaceae family, is renowned in Ayurveda for its medicinal properties found in its stem bark, leaves, and seeds. Over the years, researchers have isolated various phytochemical compounds from this plant, demonstrating their traditional pharmacological effects, including analgesic, antibacterial, anti-diarrheal, anti-diabetic, antioxidant, anti-urolithic, and anti-inflammatory activities. Furthermore, recent studies have unveiled novel activities such as angiotensin-converting-enzyme inhibition, acetylcholinesterase inhibition, anti-amnesic effects, and neuroprotective properties. This review aims to shed light on the therapeutic potential of Holarrhena antidysenterica for various diseases

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How to Cite
Manthan M. Thawkar, Maroti M. Jeurkar, Mohit G. Saktel, & Satish P. Mohitkar. (2024). Phyto-Pharmacology Profile Of Holarrhena Antidysenterica: A Review. Journal of Advanced Zoology, 45(2), 1294–1299. https://doi.org/10.53555/jaz.v45i2.4123
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Articles
Author Biographies

Manthan M. Thawkar

Research scholar. Department of Pharmacognosy

 

Maroti M. Jeurkar

Assistant professor, Institute of Pharmacy. Maregaon

Mohit G. Saktel

Research scholar, Department of Pharmaceutics

Satish P. Mohitkar

Associate Professor, Hi-Tech College of Pharmacy. Chandrapur

References

Ali KM, Chatterjee K, De D, Bera TK, Ghosh D. Efficacy of aqueous extract of seed of Holarrhena Antidysenterica for the management of diabetes in the experimental model rat: A correlative study with antihyperlipidemic activity. International Journal of Applied Research in Natural Products. 2009; 2(3): 13-21.

Ali KM, Chatterjee K, Dea D, Janaa K, Beraa TK, Ghosha D. Inhibitory effect of hydro-methanolic extract of seed of Holarrhena Antidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rat. Journal of Ethnopharmacology.2011; 135: 194–196. 19.

Bansal N, Singh N, Mrinal. Holarrhena Antidysenterica Extract Promotes Recovery of Peripheral Neuropathy in Diabetic Rats. Am. J. PharmTech Res. 2016; 6(4): 2249-3387.

Berg JM, Tymoczko JL, Stryer L. Glycolysis and gluconeogenesis. In: Biochemistry.

Berg JM, Tymoczko JL, Stryer L. (Eds). W.H. Freeman: New York. 2001; 425-464.

Darji VC, Deshpande S, Bariya AH. Comparison between the effect of aqueous and methanolic extracts of Holarrhena Antidysenterica bark against experimentally induced inflammatory bowel disease. IRJP; 2013, 4 (1): 131-134.

Das D. 2002. Biochemistry, 11th edition, Kolkata, Academic Publishers, pp-448.

Dey A, De JN. Ethnobotanical Survey of Purulia district, West Bengal, India for medicinal plants used against gastrointestinal disorders. J Ethnopharmacol. 2012; 143:68-80.

Dua VK, Verma G, Singh B, Rajan A, Bagai U, Agarwal DD, Gupta NC, Kumar S, Rastogi A. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malaria journal. 2013 Dec;12(1):194.

Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961; 7(2): 88-95

Ganapathy PS, Ramachandra YL, Rai SP. In vitro antioxidant activity of Holarrhena Antidysenterica Wall. Methanolic leaf extract. J. Bsic. Clin. Pharm. 2011; 2: 175-178.

Ganapathy PSS, Ramachandra YL, Rai SP. Anti-inflammatory and analgesic activities of Holarrhena antidysenterica Wall. Leaf extract in experimental animal models. IJBPS. 2010; 4(2):101-103.

Gupta K, Karale S, Warad V. Anti-diarrhoeal activity of a polyherbal formulation in various animal models of diarrhea. IRJP. 2012; 3(8): 289-290.

Jamadagni PS, Pawar SD, Jamadagni SB, Chougule S, Gaidhani SN, and Murthy SN. Review of Holarrhena Antidysenterica (L.) Wall. Ex A. DC. Pharmacognostic, Pharmacological, and Toxicological Perspective. Pharmacogn Rev. 2017;11(22): 141–144.

Kavitha D, Shilpa PN & Devaraj SN. Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena Antidysenterica WALL. Indian Journal of Experimental Biology. 2004; 42: 589-594.

Khan A, Khan SR, and Gilani AH. Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica. Urol Res. 2012; 40:671–681.

Kumar N, Singh B, Bhandari P, Gupta AP, and Kaul VK. Steroidal Alkaloids from Holarrhena Antidysenterica (L.) WALL. Chem. Pharm. Bull. 2007; 55(6): 912-914.

Lin J, Opoku AR, Geheeb-Keller M, Hutchings AD, Terblanche SE, Jager AK, Van Staden J. Preliminary screening of some traditional Zulu medicinal plants for anti-inflammatory and antimicrobial activities. J. Ethnopharmacol. 1999; 68: 267-274.

Mahato S, Mehta A and Roy S. Studies on antibacterial effects of bark, seed, and callus extracts of Holarrhena Antidysenterica wall. The Bioscan. 2013; 8(2): 717-721

Mana S, Singhal S, Sharma NK, Singh D. Hypoglycemic Effect of Holarrhena Antidysenterica Seeds on Streptozotocin-induced Diabetic Rats. International Journal of PharmTech Research. 2010; 2(2): 1325-1329.

Mrinal, Navjeet Singh, Nitin Bansal. Anti-amnesic Activity of Holarrhena Antidysenterica Extract in Streptozotocin-Induced Memory Deficient Rats. Sch. Acad. J. Pharm. 2016; 5(8): 317-325.

Orhan I, Sener B, Choudhary, Khalid A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J Ethnopharmacol. 2004; 91(1): 57-60.

Paranjpe P, Patki P, Joshi N. Efficacy of an indigenous formulation in patients with bleeding piles: a preliminary clinical study. Fitoterapia. 2000; 71:41–45.

Parekh J and Chanda S. In vitro antimicrobial activities of extract of Launaea procumbens Roxb.(Labiateae), Vitis vinifera (Vitaceae) and Cyperus. rotundus (Cyperaceae). Afr. J. Biomed. Res., 2006; 9: 89-93.

Patel MV, Patel KB, Gupta SN. Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis. Ayu. 2010; 31:478–481.

Sharma DK, Gupta VK, Kumar S. Evaluation of antidiarrheal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats. Veterinary World. 2015; 8(4): 1392-1395.

Sharma U & Velpandian T & Sharma P & Singh S. Evaluation of anti-leishmanial activity of selected Indian plants known to have antimicrobial properties. Parasitol Res. 2009; 105: 1287–1293.

Shwetha C, Latha KP, Asha K. Study on analgesic activity of Holarrhena antidysenterica leaves. International Journal of Herbal Medicine. 2014; 2(3): 14-16.

Sinha S, Sharma A, Reddy PH, Rathi B, Prasad N.V.S.R.K., Vashishtha A. Evaluation of phytochemical and pharmacological aspects of Holarrhena Antidysenterica (Wall.): A comprehensive review. Journal of pharmacy research. 2013; 6: 488-492.

Umashanker KPd, Chandra S, Sharma J. Antidiabetic Efficacy Of Ethanolic Extract of Holarrhena Antidysenterica Seeds in Streptozotocin–Induced Diabetic Rats and Its influence on certain Biochemical Parameters. Journal of Drug Delivery & Therapeutics. 2012; 2(4); 159-162.

Yang ZD, Duan DZ, Xue WW, Yao XJ, Li S. Steroidal alkaloids from Holarrhena Antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships. Life Sciences. 2012; 90: 929-933.

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