Minimum Inhibitory Concentration Of Different Effective Antibiotics Against Oral Staphylococcus Aureus Isolated From Diabetic Patients
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Abstract
Bacterial sialadenitis is common in diabetics, and Staphylococcus aureus (SA) is the causative agent. Prescription of empiric antibiotics to eliminate bacteria is the best treatment in these cases. The purpose of this study was to investigate the effect of Minimum Inhtionibitory Concentration (MIC) of second, third, and fourth generation of cephalosporins as well as oxacillin against SA.
Methods: In this study, 247 samples were collected from the parotid duct opening from type II diabetes patients. The samples were transferred to the laboratory in BHIB medium and were subjected to culture and biochemical diagnostic tests to isolate and detect SAMIC of Cefuroxime, Ceftriaxone, cefepime, cloxacillin, oxacillin against SA determined by broth microdilution method. The results were analyzed by SPSS18.
Results: Among 247 type 2 diabetic patients, Staphylococcus aureus was isolated from 61 patients (39 women, 22 men). 51, 46, 52 and 60 people were sensitive to 2nd, 3rd, 4th generation cephalosporin antibiotics and oxacillin, respectively. Of these, the lowest to the highest average MIC values were related to oxacillin, cefuroxime, cefepime and ceftriaxone. The average MIC in three antibiotics, oxacillin, methicillin, and cloxacillin, respectively was 0.71±0.69, 6.24±4.04, 40.08± 33.23. The type of antibiotic used had a significant relationship with resistance and sensitivity. Sensitivity to oxacillin, methicillin and cloxacillin was observed in in 98.4%, 85.2% and 75.4% of patients.
Conclusions: Oxacillin showed significantly the lowest MIC compared to methicillin and cloxacillin. Therefore, it can be a recommended antibiotic for infections caused by staph aureus to be administered to diabetics. Based on our results, oxacillin can be a suitable treatment option in diabetic patients with bacterial sialadenitis. If oxacillin is not available, second generation cephalosporin (cefuroxime) can be used against SA.
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