Formulation And Evaluation Of Antidiarrhoeal Activity Of Ethanolic Leaf Extract Of Prunus Avium And Cedrus Deodara In Swiss Albino Mice

Abstract

Traditionally, the leaves of Prunus Avium and Cedrus Deodara have been used to treat diarrhoea. Its effectiveness hasn't been scientifically proven, though, thus far. This study looked at the antidiarrheal properties of Prunus Avium and Cedrus deodara leaf extracts in mouse models. In models of Swiss Albino mice, the antidiarrheal efficacy of ethanolic leaf extracts of Prunus Avium and Cedrus Deodara was investigated. The extract's effects at various dosages were contrasted with those of common medications and mouse groups used as negative controls. While the number of wet feces was significantly reduced by the extract at all tested dosages, a dose of 600 mg/kg of castor oil-induced diarrhoea showed a considerable reduction in the frequency of defecation. Additionally, at all tested doses, it demonstrated a noteworthy and dose-dependent decrease in the mouse model's intestinal content; the observed findings at 400 and 600 mg/kg were superior to those of loperamide, the standard medication. At any of the tested doses, a substantial antimotility impact was not seen, nevertheless. These findings indicate that the ethanolic leaf extracts of Cedrus deodara and Prunus avium exhibited antidiarrheal properties