Recent Advances In Synthetic Developments Of Flavonoids: A Comprehensive Overview
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Abstract
Being ability to produce molecules with high enantiomeric purity and biological interest makes synthesis an increasingly useful technology. Flavonoids are organic substances having a variety of biological functions. Numerous methods of stereoselective synthesis have been used in order to produce enantiomerically pure forms and take use of their biological potential. These methods include the cycloaddition of 1,4-benzoquinone, Mitsunobu reaction, Sharpless asymmetric dihydroxylation, and chalcone epoxidation. In order to produce chiral bioactive flavonoids with a high enantiomeric ratio, chiral auxiliaries, organometallic, biocatalytic, and chiral auxiliaries were also used. There have also been reports of the Diels-Alder reaction being used to create pure enantiomers of flavonoids utilising catalyst complexes or a racemic mixing approach based on the stereodivergent reaction. As evidenced by the asymmetric coupling of 2-hydroxychalcones triggered by visible light, biomimetic routes also demonstrated a different strategy. The recent synthesis of (R,R)-cis-alcohols, which will serve as the building blocks for the stereoselective synthesis of flavonoids, also utilised an asymmetric transfer hydrogen-dynamic kinetic resolution.
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