Anti-Diabetic Evaluation Of The Traditional Siddha Polyherbal Formulation - Madhu Mukthi Kudineer Chooranum By In Silico Analysis
Main Article Content
Abstract
Background: From ancient times Siddha medicines have been proven to treat a wide range of communicable and noncommunicable diseases. In India, the number of people affected with diabetes is increasing drastically and it is considered as an epidemic.
Purpose: To assess the anti-diabetic activity of the active compounds of the polyherbal formulation – Madhu Mukthi Kudineer Chooranum (MKC) by docking against potent enzymes involved in diabetes mellitus by in silico method.
Methods: The major target enzymes Dipeptidyl peptidase, Glycogen synthase kinase - 3β, Alpha-glucosidase and Alpha-amylase were docked against the 10 active compounds present in the MKC using Auto Dock tools.
Conclusion: The strong interactions between the target enzymes and the active compounds proved the anti-diabetic efficacy of the MKC formulation. Thus, the intake of MKC has potential benefits in the treatment of Type II Diabetes Mellitus.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Alzohairy, Mohammad A. 2016. “Therapeutics Role of Azadirachta Indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment.” Evidence-based Complementary and Alternative Medicine 2016.
Dr.R.S. Lekshmi1, Dr.K. Jawaharrani2, Dr.J.Srilekha3, Mr.Suresh.K. 2023. “FAMILIARITY EXPERIENCE AND PREFERENCE FOR SIDDHA TREATMENT.” Journal of Pharmaceutical Negative Results 14(02): 1823–32.
Krupanidhi, S. et al. 2020. “Screening of Phytochemical Compounds of Tinospora Cordifolia for Their Inhibitory Activity on SARS-CoV-2: An in Silico Study.” Journal of Biomolecular Structure and Dynamics: 1–5.
Lakshmanakumar, Venkatachalam et al. 2023. “Molecular Docking Analysis to Validate the Efficacy of Traditional Siddha Polyherbal Formulation Aavarai Bhavanai Chooranam (ABC) against Enzyme Alpha-Glucosidase for Type II Diabetes Mellitus.” TMR Integrative Medicine 7(0): e23001.
Maiti, Suraj, Shamrin Akhtar, Ashish Kumar Upadhyay, and Sanjay K. Mohanty. 2023. “Socioeconomic Inequality in Awareness, Treatment and Control of Diabetes among Adults in India: Evidence from National Family Health Survey of India (NFHS), 2019–2021.” Scientific Reports 13(1): 1–12. https://doi.org/10.1038/s41598-023-29978-y.
Mandal, Sumit Kumar et al. 2023. “In Silico Anti-Viral Assessment of Phytoconstituents in a Traditional (Siddha Medicine) Polyherbal Formulation – Targeting Mpro and Pan-Coronavirus Post-Fusion Spike Protein.” Journal of Traditional and Complementary Medicine 14(1): 55–69.
Mudaliyar, Vaithiya Rathnam K. S. Murugesa. “No Title.” In Gunapadam Medicinal Plants Division, Directorate of Indian Medicine and Homeopathy, , p147.
New Delhi, Govt.of India, Ministry of Health and Family welfare, Department of AYUSH. 2011. Siddha Pharmacopoeia of India Part 1 Vol 2 First Edition.
Oboh, Ganiyu, Adelusi Temitope Isaac, Ayodele Jacobson Akinyemi, and Richard Akinlolu Ajani. 2014. “Inhibition of Key Enzymes Linked to Type 2 Diabetes and Sodium Nitroprusside Induced Lipid Peroxidation in Rats’ Pancreas by Phenolic Extracts of Avocado Pear Leaves and Fruit.” International Journal of Biomedical Science 10(3): 210–18.
Palpandian, .Asan R. 2019. 2nd Edition Siddhas Masters of Nature, Devotees of Sri Sri Ravi Shankar Ashram.
Palpandian. Asan R. Nature Mmics, Thiruvannamalai, Earth India Siddha Private Limited, Tamilnadu, ISBN: 978-935351093
Ponnusamy, Revathi et al. 2022. “Glycogen Synthase Kinase 3β Inhibition and Insulin-Receptor Binding Enhancement of Compounds Isolated from Wild Leafy Vegetable Acalypha Alnifolia.” Phytomedicine Plus 2(1): 1–22.
Rahman, Shahedur, and Rashida Parvin. 2014. “Therapeutic Potential of Aegle Marmelos (L.)-An Overview.” Asian Pacific Journal of Tropical Disease 4(1): 71–77.
Rahmani, Arshad H. 2015. “Cassia Fistula Linn: Potential Candidate in the Health Management.” Pharmacognosy Research 7(3): 217–24.
Raut, Bimal K., Siddha Raj Upadhyaya, Jyoti Bashyal, and Niranjan Parajuli. 2023. “In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor.” ACS Omega 8(46): 43617–31.
Saravana Babu, Chidambaram et al. 2012. “Polyphenols in Madhumega Chooranam, a Siddha Medicine, Ameliorates Carbohydrate Metabolism and Oxidative Stress in Type II Diabetic Rats.” Journal of Ethnopharmacology 142(2): 331–36.
Sujata, Basu, Mamta Pant, and Rachana. 2013. “Phytochemical Evaluation and Hptlc Profiling of Extracts of Salacia Oblonga.” International journal of Pharmaceutical Sciences and Research 4(4): 1409–18.