Formulation and Evaluation of Bilayer Floating Tablets
Main Article Content
Abstract
The aim of the present study is to formulate and evaluate the bilayer tablets
of Atorvastatin and Ramipril using different media, to know the release
studies in which media the release of the drug is in controlled manner. The
bilayer tablets of Atorvastatin matrix floating and Ramipril immediate
release tablets were prepared. Bi-Layer tablets consists of two layers
i.e.,immediate release layer containing of disintegrant sodium starch
glycollate and controlled release layer containing HPMCK100M, POLY0X
WSR 303 and sodium alginate asretard layer. Combination of Atorvastatin
and ramipril prepared by direct compression and wet granulation method
which consists of various disintegrants and polymer in different ratios The
tablets were evaluated for various parameters like weight variation,
thickness, hardness and friability. The release studies were carried out using
different media using USP dissolution testing apparatus II (paddle type) for
12hrs
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