Sustained Released Opthalmic in Situ Hydrogel Of Levofloxacin From A Ph-Triggered In Situ Gelling
DOI:
https://doi.org/10.53555/jaz.v45i2.3806Keywords:
Carbopol 934, in situ gelling ophthalmic delivery system, levofloxacin hemihydrateAbstract
Background: Most of eye diseases are treated with topical application of eye drops. The poor bioavailability and therapeutic response exhibited by these conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling system that are instilled as drops into the eye drops and undergo a sol-to-gel transition in the cul-de-sac.
Objective: The purpose of the present work was to develop sustain ophthalmic delivery to levofloxacin from a ph-triggered in situ gelling system.
Method: Polyacrylic acid (Carbopol 934) was used as the gelling agent in combination with hydroxypropyl methylcellulose (Methocel K4M) and HPMC K100LV which acted as viscosity enhancing agent. Compatibility studies of the drug excipients were carried out using FTIR.
Result: The prepared formulation were characterized for clarity, pH, drug content, gelling capacity, rheological studies, in vitro drug release study, sterility study and stability study. It is observed that the formulated system provided sustained release of drug for more than 8 hrs period.
Downloads
References
worakul N., Robinson J. R.. Ocular pharmacokinetics / pharmacodynamics. Eur. J. Pharm. Biopharm., 1997; 44: 71-83.
Jarvinen K., Jarvinen T., Urtti A.. Ocular absorption following topical delivery. Adv. Drug Del. Rev., 1995; 6: 3-19.
Schoenwald T. J . Ocular drug delivery: pharmacokinetic considerations. Cli. pharmacokinet., 1990; 18: 255-269.
Middleton D.L., Leung S.S., Robinson J. R.. Bioadhesive Drug Delivery system. CRC Press, Boca Raton, 1990; 179-202.
Thermes F, Roizer A., Plazonnet B., et al. Bioadhesion the effect of Polyacrylic acid on the ocular bioavailability of timolol. Int. J. pharm., 1992; 81: 59-65
Felt O., Furrer P., Mayer J. M., et al. Topical use of chitosan in ophthal mology: tolerance assessment and evaluation of precorneal retention.Int. J. Pharm., 1999 ; 180 : 185-193.
Sechoy O, Tissie G., Sebastian C., et al. A new long acting ophthalmic formulation of carteolol containing alginic acid. Int. J. pharm., 2000; 207: 109-116.
Gurny R., Boye T., Ibrahim H.. Ocular therapy with nanoparticle system for controlled drug delivery. J. control. Rel.,1985; 2 : 353-361.
Miller S. C., Donovan M.D.. Effect of poloxamer 407 gel on the mitotic activity of pilocarpine nitrate in rabbits. Int. J. pharm., 1982; 2 : 353-361.
Spancake C. W., Mitra A.k., Kildsig D. O.. kinetics of aspirin hydrolysis in aqueous solution and gels of poloxamines (Tetronic 1508). Influence of microenvironment. Int. J . pharm., 1991; 75: 231-239.
Rozier A., Manuel C., Groove J., et al. Gelrite: A novel, ion- activated, in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol. Int. J . pharm. 1989; 57: 163-168.
Sanzgiri Y. D., Maschi S., Crescenzi V., et al. Gellan based system for ophthalmic sustained delivery of methylprednisolone. J . control. Rel., 1993; 26 : 195-201.
Pavia Donald L., Lampman Gary M., Kriz George S., introduction to spectroscopy, Third edition :13-101.
Srividya B, Rita M, Cardoza, Amin PD Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. J Control Release. 2003; 30: 129-138.
Eaga Chandra Mohan, Jagan Mohan KanduKuri, Venkateshan Allenki. Preparation and Evaluation of Insitu Gels for Ocular Drug Delivery. J Pharm Res. 2009; 2(6): 1089-1094.
Balasubramaniam, J.et al In vitro and in vivo evaluation of the Gelrite gellan gum‐based ocular delivery system for indomethacin. Acta Pharm., (2003). 53, 251–261.
Sindhu Abraham, Sharon Furtoda, Bharath S, Basavaraj BV, Deveswaran R and Madhavan N. Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system. Pak J Pharm Sci. 2009; 22 (2): 175- 179.
Naseem A, Charoo, Kanchan Kohhli, Asgar Ali. Preparation of in situ forming ophthalmic gels of ciprofloxacin Hydrochloride for the treatment of Bacterial Conjunctivitis: In vitro and in vivo Studies. J Pharm Sci, 2003; 92 (2): 407-415.
Satish kumar P et al: In situ ophthalmic gel of Ciprofloxacin Hydrochloride for once a day sustained delivery. Drug Development and Industrial Pharmacy, 34:445–452, 2008.
Indu, P., Kaur, A.G., Anil, K.S., eepika, A. Vesicular systems in ocular drug delivery an overview. Int J Pharm. 2004; 269: 1–14. [221Hdoi:10.1016/j.ijpharm. 2003.09.016]
Wagh VD, Inamdar B, Samanta MK. Polymers used in ocular dosage form and drug delivery systems. Asian J Pharma. 2008; 12–17. 6. Indu, P., Kaur, A.G., Anil, K.S., eepika, A.Vesicular systems in ocular drug delivery an overview.Int J Pharm. 2004; 269: 1–14.[221Hdoi:10.1016/j.ijpharm.2003.09.016]
Singh Satish K., Bandyopadhya, Paramita.Pharmacia Corporation. Ophthalmic formulation with novel gum composition.US 7128928, 2006.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Dr. Suchita Gokhale, Dr. Pritam Juvatkar, Dr. Smita Takarkhede, Dr. Pritam Khandave, Ms. Vrushali Neve, Ms. Jaymala Arun Kumawat, Mr. Sahil M
This work is licensed under a Creative Commons Attribution 4.0 International License.
