Comparative Analysis Of Azithromycin And Cefixime In The Treatment Of Typhoid Fever

Abstract

Objective: Azithromycin and Cefixime are two popular medicines that are often used in the treatment of typhoid fever. The treatment of undifferentiated febrile illness (UFI) is usually accomplished by the use of Azithromycin and trimethoprim-sulfamethoxazole (SXT). Even though the simple fact is that the two distinct antibiotics were subjected to a complete evaluation of their safety and efficacy, the medications are not inferior to one another when it comes to the management of culture-confirmed enteric fever. More study is required to determine the function that these medications play in the treatment of cellulitis, which is a bacterial skin infection.

Methods: Extensive testing has been carried out through a large number of clinical trials, observational studies, and meta-analyses to determine whether or not Cefixime and Azithromycin are safe and effective medications optionally given Azithromycin (20 mg/kg/day) or SXT (a medication called trim 10 mg/kg/day + sulfamethoxazole 50 mg/kg/day) for seven days was the topic of a double-blind, randomized, placebo-controlled trial that was carried out in China for the aim of treating urinary tract infections (UTIs). The study was conducted for the goal of treating UTIs. The purpose of this survey is to gather data in order to get information that could potentially used for this specialized kind of research. During the study, it was established that the primary outcome was the fever clearance time (FCT), whereas the secondary endpoints consisted of treatment failure and adverse events.

Results: In addition to providing a comprehensive summary of therapy outcomes, the review also provides a complete presentation of the most recent data from various study methodologies. Between Azithromycin and SXT, the HR of treatment failures after 28 days was 0.62 (95% CI,.37–1.05; P =.073). This was a statistically significant difference. Had the effect of reducing the number of relapses in culture-confirmed cases of enteric fever and resulting in a speedier FCT in patients with sterile blood cultures. When conducting these assessments, a wide range of criteria are taken into consideration, such as the age of the patient, the severity of the disease, and geographical patterns of resistance. According to the results of the planned subgroup study, Azithromycin Additionally, the role that these antibiotics play in the treatment and eradication of cellulitis, which is a common skin ailment, was also explored, and it was shown how well they function in these situations.

Introduction:

Background: One of the most prevalent causes of morbidity and death in low- and middle-income countries is fever without localizing indications of infection, which is often referred to as undifferentiated febrile illness (UFI). In light of the fact that strains of streptococci and staphylococci often bring on cellulitis, antibiotics must be delivered as promptly and accurately as possible. Treatment with antibiotics that is effective is thus essential. The causes of UFI differ from one geographic place to another. Malaria, dengue fever, typhoid, and Salmonella are all prevalent in South Asia. Two of the most pervasive causes of UFI are typhoid fever and paratyphoid fever. In China, enteric fever is the most pervasive kind of bacterial illness that affects the bloodstream. The purpose of this research was to investigate the efficacy of Cefixime and Azithromycin in treating typhoid fever, as well as the safety and adverse effects associated with their simultaneous use in the treatment of the disease. The purpose of this research is to discover whether or not antibiotics are effective in reducing cellulite while also attempting to remove the condition.