Formulation Optimization And Evaluation Of Drug Loaded Nanosponges For Oral Drug Delivery
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Abstract
Depression is treated with venlafaxine HCL, Additionally, it is used to treat panic disorder, social anxiety disorder, and generalised anxiety disorder. The main goal of this study was to prepare venlafaxine HCL loaded nanosponges into tablets for an oral purpose by using Box-Behnken design to increase the bio availability. The drug was placed into nanosponges utilising the hot-melt compression technique, three-dimensional colloidal nanosponges were prepared by using β-cyclodextrin and dimethyl carbonate as a cross-linker. The effect of three Independent variables such as β cyclodextrin, dimethyl carbonate and response on two dependent variables vesicle size and entrapment efficiency were investigated. With the help of box behnken design 15 formulations were prepared out of which formulation 10 was considered as optimized based on the drug EE. The nanosponge formulations were evaluated for particle size, percent drug entrapment, shape and surface morphology, drug content, and in vivo drug release studies. The prepared nanosponge had a particle size of 257.6 nm, a drug entrapment percentage of 97.42 percent, and was almost spherical in shape. Utilizing HPMC K4M, the formulations NA1 through NA15 matrix tablets were crushed into drug-loaded nanosponges for 24 hours.
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