Effect of Antioxidants on Semen Parameters on SOAT Pt: An Observational Study in Rural Population

Main Article Content

Khushboo Upadhyaya
Dr Rukhsheen Khan

Abstract

This article aims to investigate the effect of antioxidants on semen parameters in the rural population. Male infertility is a growing concern worldwide, and there is evidence emphasizing oxidative stress as a significant contributing factor. Antioxidants have gained attention for their potential role in mitigating the damaging effects of oxidative stress on semen health. This observational study carefully evaluates the impact of antioxidant supplementation on semen parameters in a rural population, contributing to the existing literature on male reproductive health.

Downloads

Download data is not yet available.

Article Details

How to Cite
Khushboo Upadhyaya, & Dr Rukhsheen Khan. (2023). Effect of Antioxidants on Semen Parameters on SOAT Pt: An Observational Study in Rural Population. Journal of Advanced Zoology, 44(5), 894–906. https://doi.org/10.53555/jaz.v44i5.3301
Section
Articles
Author Biographies

Khushboo Upadhyaya

M.sc  biotechnology ,clinical embryologist, Index Medical College and Hospital and Research Centre,Indore

Dr Rukhsheen Khan

MBBS, MS OBGY 3rd year PG resident, Index medical college and hospital and research centre

References

Lafuente R, González-Comadrán M, Solà I, López G, Brassesco M, Carreras R, et al. Coenzyme Q10 and male infertility: a meta-analysis. J Assis Reprod Gen. 2013;30:1147–1156. [PMC free article] [PubMed] [Google Scholar]

Makker K, Agarwal A, Sharma R. Oxidative stress & male infertility. Ind J Med Res. 2009;129:357–367. [PubMed] [Google Scholar]

Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int. 2005;95:503–507. [PubMed] [Google Scholar]

Saleh RA, HCLD AA. Oxidative stress and male infertility: from research bench to clinical practice. J Androl. 2002;23:737–752. [PubMed] [Google Scholar]

Eskenazi B, Kidd S, Marks A, Sloter E, Block G, Wyrobek A. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod. 2005;20:1006–1012. [PubMed] [Google Scholar]

Rao B, Soufir J, Martin M, David G. Lipid peroxidation in human spermatozoa as relatd to midpiece abnormalities and motility. Gamete Res. 1989;24:127–134. [PubMed] [Google Scholar]

Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005;6:495–501. [PubMed] [Google Scholar]

Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl. 2005;26:349–353. [PubMed] [Google Scholar]

Greco E, Romano S, Iacobelli M, Ferrero S, Baroni E, Minasi MG, et al. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Hum Reprod. 2005;20:2590–2594. [PubMed] [Google Scholar]

Garolla A, Maiorino M, Roverato A, Roveri A, Ursini F, Foresta C. Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels. Fertil Steril. 2005;83:355–361. [PubMed] [Google Scholar]

Katole A, Saoji AV. Prevalence of primary infertility and its associated risk factors in urban population of central India: a community-based cross-sectional study. Indian J Community Med. 2019;44:337–341. [PMC free article] [PubMed] [Google Scholar]

World Health Organization. Infertility: a tabulation of available data on prevalence of primary and secondary infertility. Geneva: World Health Organization; 1991. [Google Scholar]

Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. [PMC free article] [PubMed] [Google Scholar]

Karavolos S, Stewart J, Evbuomwan I, McEleny K, Aird I. Assessment of the infertile male. Obstet Gynecol. 2013;15:1–9. [Google Scholar]

Hossain MA, Naser MF, Azam MS, Islam MW, Biswas NP, Bhuiyan AM, et al. Male Infertility: Causes and Optimal Evaluation. Bangladesh J Urol. 2016;9:43–48. [Google Scholar]

World Health Organization. WHO laboratory manual for the examination and processing of human semen. Geneva: World Health Organization; 2010. [Google Scholar]

Cavallini G. Clinical management of male infertility. Cham: Springer; 2015. [Google Scholar]

Coutton C, Escoffier J, Martinez G, Arnoult C, Ray PF. Teratozoospermia: spotlight on the main genetic actors in the human. Hum Reprod Update. 2015;21:455–485. [PubMed] [Google Scholar]

Majzoub A, Agarwal A. Antioxidant therapy in idiopathic oligoasthenoteratozoospermia. Indian J Urol. 2017;33:207–214. [PMC free article] [PubMed] [Google Scholar]

Dorostghoal M, Kazeminejad SR, Shahbazian N, Pourmehdi M, Jabbari A. Oxidative stress status and sperm DNA fragmentation in fertile and infertile men. Andrologia. 2017;49:e12762 [PubMed] [Google Scholar]

Osaka A, Okada H, Onozuka S, Tanaka T, Iwahata T, Shimomura Y, et al. Evaluation of the sperm DNA fragmentation index in infertile Japanese men by in-house flow cytometric analysis. Asian J Androl. 2022;24:40–44. [PMC free article] [PubMed] [Google Scholar]

Giahi L, Mohammadmoradi S, Javidan A, Sadeghi MR. Nutritional modifications in male infertility: a systematic review covering 2 decades. Nutr Rev. 2016;74:118–130. [PMC free article] [PubMed] [Google Scholar]

Du Plessis SS, Agarwal A, Halabi J, Tvrda E. Contemporary evidence on the physiological role of reactive oxygen species in human sperm function. J Assist Reprod Genet. 2015;32:509–520. [PMC free article] [PubMed] [Google Scholar]

Harris ID, Fronczak C, Roth L, Meacham RB. Fertility and the aging male. Rev Urol. 2011;13:e184–e190. [PMC free article] [PubMed] [Google Scholar]

Balercia G, Regoli F, Armeni T, Koverech A, Mantero F, Boscaro M. Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril. 2005;84:662–671. [PubMed] [Google Scholar]

Lewis SE, John Aitken R, Conner SJ, Iuliis GD, Evenson DP, Henkel R, et al. The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment. Reprod Biomed Online. 2013;27:325–337. [PubMed] [Google Scholar]

Majzoub A, Agarwal A, Esteves SC. Antioxidants for elevated sperm DNA fragmentation: a mini review. Transl Androl Urol. 2017;6:S649–S653. [PMC free article] [PubMed] [Google Scholar]

Ménézo YJ, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online. 2007;14:418–421. [PubMed] [Google Scholar]

Moskovtsev SI, Lecker I, Mullen JB, Jarvi K, Willis J, White J, et al. Cause-specific treatment in patients with high sperm DNA damage resulted in significant DNA improvement. Syst Biol Reprod Med. 2009;55:109–115. [PubMed] [Google Scholar]

Zhaku V, Beadini S, Beadini N, Amzai G. Oral antioxidants mitigate levels of malondialdehyde and protein carbonyl and improve semen parameters in men with oligoasthenozoospermia. Research Square. 2020 July 30; doi: 10.21203/rs.3.rs-49942/v1. [CrossRef] [Google Scholar]

Micic S, Lalic N, Djordjevic D, Bojanic N, Bogavac-Stanojevic N, Busetto GM, et al. Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. Andrologia. 2019;51:e13267. [PMC free article] [PubMed] [Google Scholar]

Busetto GM, Agarwal A, Virmani A, Antonini G, Ragonesi G, Del Giudice F, et al. Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study. Andrologia. 2018;50:el2927 [PubMed] [Google Scholar]

Akmal M, Qadri JQ, Al-Waili NS, Thangal S, Haq A, Saloom KY. Improvement in human semen quality after oral supplementation of vitamin C. J Med Food. 2006;9:440–442. [PubMed] [Google Scholar]

Tikkiwal M, Ajmera RL, Mathur NK. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol. 1987;31:30–34. [PubMed] [Google Scholar]

Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. Antioxidant supplements and semen parameters: an evidence based review. Int J Reprod Biomed. 2016;14:729–736. [PMC free article] [PubMed] [Google Scholar]

Vishvkarma R, Alahmar AT, Gupta G, Rajender S. Coenzyme Q10 effect on semen parameters: profound or meagre? Andrologia. 2020;52:e13570. [PubMed] [Google Scholar]

Blomberg Jensen M, Lawaetz JG, Petersen JH, Juul A, Jørgensen N. Effects of vitamin D supplementation on semen quality, reproductive hormones, and live birth rate: a randomized clinical trial. J Clin Endocrinol Metab. 2018;103:870–881. [PubMed] [Google Scholar]

Scaruffi P, Licata E, Maccarini E, Massarotti C, Bovis F, Sozzi F, et al. Oral antioxidant treatment of men significantly improves the reproductive outcome of IVF cycles. J Clin Med. 2021;10:3254. [PMC free article] [PubMed] [Google Scholar]