Hepatoprotective Effect Of Allium Sativum And Acarus Calamus Extract In Cisplatin Induced Hepatotoxicity In Experimental Rats
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Abstract
The purpose of this research was to determine whether or not allium sativum and acarus calamus had a protective effect against the hepatotoxic effects of cisplatin when administered to experimental rats. The methods included randomly assigning rats to one of five different groups. Cisplatin was administered at a dosage of 7.5 mg/kg, which resulted in the induction of hepatotoxicity. Serum levels of AST, ALT, total bilirubin, and albumin, as well as hepatic hydroxy proline (HP), reduced glutathione (GSH), and malondialdehyde (MDA), cytokines, and NO were assessed. The findings of this research demonstrated that therapy with allium sativum and acarus calamus led to normal body and liver weights, but treatment with cisplatin led to reduced body weight and increased liver weight in rats. Cisplatin-treated rats exhibited elevated levels of serum AST, ALT, total bilirubin, HP, GSH, MDA, and cytokines. The administration of allium sativum and acarus calamus to rats resulted in a decrease in the oxidative stress, an inhibition of the production of cytokines in a dose-dependent manner, and protection against hepatotoxicity. Allium sativum and acarus calamus were shown to have a protective effect against the hepatotoxicity caused by cisplatin, as was concluded by the research.
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