Cassia Fistula Linn: A Comprehensive Review and Future Research Directions

Main Article Content

Naina
Sunaina
Phool Chandra

Abstract

Cassia fistula belongs to the family Fabaceae commonly known as Golden Shower, Amaltas.It is also called Pudding Pipe tree. In Ayurvedic system of medicine, different parts (leaves, flowers, Roots, and Fruit pulp) of Cassia fistula Linn have been recommended for the treatment of Jaundice, Gout, Fatty Liver, Liver Disorder, Bronchitis, Fever, Skin disease, and so on. The Cassia fistula Linn has also been suggested to possess, anti-diabetic, rheumatic disorder, leprosy, diuretics. It also has blood purifier action. Cassia fistula (Amaltas), a golden shower tree belonging to the Leguminosae family with 8-15 m height. Lassig fistula stem is greenish ever reddish-brown root. Compounds leaf 3-8 pairs of leaflets, cylindrical pods and ovoid seeds. This article aims to provide a comprehensive review on the phytochemical and pharmacological aspects of Cassia fistula. The fruits, stem, bark, and leaves of this plant contain a variety of biologically active compounds such as Anthraquinone, flavonoids, flavan-3-ol derivatives, alkaloids, glycosides, tannin, saponins, reducing sugar and steroids those have various medicinal properties. The fruit and stem bark extract show various activities like antipyretic, anti-inflammatory, antioxidant, antidiabetic, hepato-protective, antimicrobial, antitumor, antiulcer etc. The article reviews the various activities of the plant.

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How to Cite
Naina, Sunaina, & Phool Chandra. (2023). Cassia Fistula Linn: A Comprehensive Review and Future Research Directions. Journal of Advanced Zoology, 44(S6), 2137–2153. https://doi.org/10.53555/jaz.v44iS6.2914
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Articles
Author Biographies

Naina

Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh-244001, India. 

Sunaina

Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh- 244001, India.

Phool Chandra

Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh-244001, India.

References

Aftab, Z., Afzal, M., Bushra, Khan, H., Badshah, S., Khan, D., Ullah, H., & Khan, S. (2019). Fistuloates A–C: New antioxidative aromatic compounds isolated from Cassia fistula. Journal of Chemical Research, 43(11–12), 516–521.

Al-Marzoqi, A., … M. H.-… of P. and, & 2016, undefined. (n.d.). Determination of metabolites products by Cassia angustifolia and evaluate antimicobial activity. Academicjournals.Org. Retrieved August 5, 2023, from https://academicjournals.org/journal/JPP/article-full-text/D4478E557364

Amber, R., Adnan, M., Tariq, A., & Mussarat, S. (2017). A review on antiviral activity of the Himalayan medicinal plants traditionally used to treat bronchitis and related symptoms. Journal of Pharmacy and Pharmacology, 69(2), 109–122. https://doi.org/10.1111/JPHP.12669

Anitha, J., Pharmscog, S. M.-I. J., & 2014, undefined. (2014). Anti-inflammatory and phytochemicals analysis of Cassia fistula Linn. fruit pulp extracts. Ijpjournal.ComJ Anitha, S MiruthulaInt J Pharmscog, 2014•ijpjournal.Com, 1(3), 207–215. https://doi.org/10.13040/IJPSR.0975-8232.IJP.1(3).207-15

Ashraf Ali, M. (2014). CASSIA FISTULA LINN: A REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES Pharmacokinetic Evaluation of Drug Loaded Nanoparticle in Animal Models View project 6. Dyslipidemia in diabetes patient is responsible for developing nephritic syndrome with increasing ages, a survey based cross sectional study View project CASSIA FISTULA LINN: A REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES. Article in International Journal of Pharmaceutical Sciences and Research, 5(6), 2125–2130. https://doi.org/10.13040/IJPSR.0975-8232.5(6).2125-30

Asif, M., Jafari, S. F., Iqbal, Z., Revadigar, V., Oon, C. E., Shah, A., Majid, A., Malik, A., & Majid, S. A. (2017). Ethnobotanical and Phytopharmacological attributes of Mesua ferrea: a mini review. Japsonline.Com, 7(04), 242–251. https://doi.org/10.7324/JAPS.2017.70435

Bahorun, T., Neergheen, V., Biotechnology, O. A.-A. journal of, & 2005, undefined. (2005).Phytochemical constituents of Cassia fistula. Ajol.InfoT Bahorun, VS Neergheen, OI AruomaAfrican Journal of Biotechnology, 2005•ajol.Info, 4(13), 1530–1540. https://www.ajol.info/index.php/ajb/article/view/71772

Baid, U., Ghodasara, S., Mohan, S., Bilello, M., Calabrese, E., Colak, E., Farahani, K., Kalpathy-Cramer, J., Kitamura, F. C., Pati, S., Prevedello, L. M., Rudie, J. D., Sako, C., Shinohara, R. T., Bergquist, T., Chai, R., Eddy, J., Elliott, J., Reade, W., … Bakas, S. (2021). The rsna-asnr-miccai brats 202. benchmark on brain tumor segmentation and radiogenomic classification. Arxiv.Org. https://arxiv.org/abs/2107.02314

Barthakur, N. N., Arnold, N. P., & Alli, I. (1995). The Indian laburnum (Cassia fistula L.) fruit: an analysis of its chemical constituents. Plant Foods for Human Nutrition, 47(1), 55–62. https://doi.org/10.1007/BF01088167

Bhakta, T., Mukherjee, P., Saha, K., … M. P.-P., & 1998, undefined. (1998). Studies on antitussive activity of Cassia fistula (Leguminosae) leaf extract. Taylor & FrancisT Bhakta, PK Mukherjee, K Saha, M Pal, BP SahaPharmaceutical Biology, 1998•Taylor & Francis, 36(2), 140–143. https://doi.org/10.1076/phbi.36.2.140.4598

Brauner, J. M., Mindermann, S., Sharma, M., Johnston, D., Salvatier, J., Gavenčiak, T., Stephenson, A. B., Leech, G., Altman, G., Mikulik, V., Norman, A. J., Monrad, J. T., Besiroglu, T., Ge, H., Hartwick, M. A., Teh, Y. W., Chindelevitch, L., Gal, Y., & Kulveit, J. (2021). Inferring the effectiveness of government interventions against COVID-19. Science, 371(6531). https://doi.org/10.1126/SCIENCE.ABD9338

Chaerunisaa, A. Y., Susilawati, Y., Muhaimin, M., Milanda, T., Hendriani, R., & Subarnas, A. (2020). Antibacterial activity and subchronic toxicity of Cassia fistula L. barks in rats. Toxicology Reports, 7, 649–657. https://doi.org/10.1016/j.toxrep.2020.04.013

Chakraborty, A. K., Saha, S., Poria, K., Samanta, T., Gautam, S., & Mukhopadhyay, J. (2022). A saponin-polybromophenol antibiotic (CU1) from Cassia fistula Bark Against Multi-Drug Resistant Bacteria Targeting RNA polymerase. Current Research in Pharmacology and Drug Discovery, 3. https://doi.org/10.1016/j.crphar.2022.100090

Danish, M., Singh, P., Mishra, G., & Srivastava, S. (2011). Cassia fistula Linn. (Amulthus)-An Important Medicinal Plant: A Review of Its Traditional Uses, Phytochemistry and Pharmacological Properties. www.scholarsresearchlibrary.com

Danish, M., Singh, P., Mishra, G., … S. S.-J. N. P. P., & 2011, undefined. (2011). Cassia fistula Linn.(Amulthus)-An important medicinal plant: A review of its traditional uses, phytochemistry and pharmacological properties. Researchgate.NetM Danish, P Singh, G Mishra, S Srivastava, KK Jha, RL KhosaJ Nat Prod Plant Resour, 2011•researchgate.Net. https://www.researchgate.net/profile/Pradeep-Singh 27/publication/216410159_Cassia_fistula_Linn_Amulthus- _An_Important_Medicinal_Plant_A_Review_of_Its_Traditional_Uses_Phytochemistry_and_Pharm acological_Properties/links/00b4951cc51c2737fe000000/Cassia-fistula-Linn-Amulthus-An- Important-Medicinal-Plant-A-Review-of-Its-Traditional-Uses-Phytochemistry-and- Pharmacological-Properties.pdf

Dave, H., & Ledwani, L. (2012). A review on anthraquinones isolated from Cassia species and their applications. Indian Journal of Natural Products and Resources, 3(3), 291–319. https://nopr.niscpr.res.in/handle/123456789/14810

Deshpande, H., medicine, S. B.-I. journal of pharma, & 2013, undefined. (2013). Recent advances in the phytochemistry of some medicinally important Cassia species: A review. Ijpmbs.Com. http://www.ijpmbs.com/uploadfile/2015/0412/20150412033315460.pdf

Duraipandiyan, V., & Ignacimuthu, S. (2007). Antibacterial and antifungal activity of Cassia fistula L.: An ethnomedicinal plant. Journal of Ethnopharmacology, 112(3), 590–594. https://doi.org/10.1016/J.JEP.2007.04.008

Ferdosi, M., Javaid, A., Khan, I., … S. K.-P. J. of, & 2021, undefined. (2021). Analysis of n-butanol flower extract of Cassia fistula through GC-MS and identification of antimicrobial compounds. Pakps.Com, 33(01), 2021–2103. https://doi.org/10.33866/phytopathol.033.01.0661

Francis, G., Dávila Ortiz, G., Martínez-Herrera, J., Siddhuraju, P., Francis, G., Dávila-Ortíz, G., & Becker, K. (n.d.). Chemical composition, toxic/antimetabolic constituents, and effects of different treatments on their levels, in four provenances of Jatropha curcas L. from Mexico. Elsevier. https://doi.org/10.1016/j.foodchem.2005.01.059

Garg, R., Silawat, N., Sairkar, P., … N. V.-A. J. of, & 2009, undefined. (2009). RAPD analysis for genetic diversity of two populations of Mystus vittatus (Bloch) of Madhya Pradesh, India. Ajol.Info, 8(17), 4032–4038. https://www.ajol.info/index.php/ajb/article/view/62124

Garima, L., & Rashmi, S. (2019). Research Paper PHARMACOLOGICAL PROPERTIES OF Cassia fistula Linn. BARK. International Journal of Pharmaceutical Erudition Www, 9(2), 59– 63. http://pharmaerudition.org/ContentPaper/2019/final%2059-63.pdf

Gobianand, K., Vivekanandan, P., … K. P.-Int. J., & 2010, undefined. (2010). Anti-inflammatory and antipyretic activities of Indian medicinal plant Cassia fistula Linn.(Golden Shower) in Wistar albino rats. Researchgate.Net. https://doi.org/10.3923/ijp.2010.719.725

Grover, J., Yadav, S., ethnopharmacology, V. V.-J. of, & 2002, undefined. (n.d.). Medicinal plants of India with anti-diabetic potential. Elsevier. Retrieved August 5, 2023, from https://www.sciencedirect.com/science/article/pii/S0378874102000594

Hafez, S., Othman, S., Ibrahim, H., … A. S.-… S. A. S., & 2019, undefined. (2019). Chemical constituents and biological activities of Cassia genus. Journals.Ekb.EgS Hafez, S Othman, H Ibrahim, A Seida, N AyoubArchives of Pharmaceutical Sciences Ain Shams University, 2019•journals.Ekb.Eg, 3(2), 195–227. https://doi.org/10.21608/aps.2019.15746.1008

Ilavarasan, R., … M. M.-A. journal of, & 2005, undefined. (2005). Anti-inflammatory and antioxidant activities of Cassia fistula Linn bark extracts. Journals. Athmsi. OrgR Ilavarasan, M Malika, S Venkataraman African Journal of Traditional, Complementary and Alternative Medicines, 2005•journals.Athmsi.Org, 2(1), 70–85. https://www.journals.athmsi.org/index.php/ajtcam/article/view/59

Irshad, M., Shreaz, S., Manzoor, N., Khan, L. A., & Rizvi, M. M. A. (2011). Anticandidal activity of Cassia fistula and its effect on ergosterol biosynthesis. Pharmaceutical Biology, 49(7), 727–733. https://doi.org/10.3109/13880209.2010.544318

Iyengar, M. A., Pendse, G. S., & Narayana, N. (1966). Bioassay of Cassia fistula. L. (Aragvadha). Planta Medica, 14(3), 289–301. https://doi.org/10.1055/S-0028-1100056

Karthikeyan, S., biology, K. G.-P., & 2010, undefined. (2010). Antiulcer activity of ethanol leaf extract of Cassia fistula. Taylor & FrancisS Karthikeyan, K GobianandPharmaceutical Biology, 2010•Taylor & Francis, 48(8), 869–877. https://doi.org/10.3109/13880200903302838

Li, J., Liu, T., Wang, L., Guo, X., Xu, T., Wu, L., … L. Q.-J. of T., & 2012, undefined. (n.d.). Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57BLKS/J db/db mice. Elsevier. Retrieved August 5, 2023, from https://www.sciencedirect.com/science/article/pii/S0254627213600539

Maity, P., Hansda, D., Bandyopadhyay, U., Dipak, &, & Mishra, K. (2009). Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos (L.) Corr. Indian Journal of Experimental Biology, 47, 849–861. https://nopr.niscpr.res.in/handle/123456789/6527

Meena, A. K., Ilavarasan, R., Perumal, A., Singh, R., Ojha, V., Srikanth, N., & Dhiman, K. S. (2022). Evaluation for substitution of stem bark with small branches of Cassia fistula Linn for traditional medicinal uses: A comparative chemical profiling studies by HPLC, LC-MS, GC-MS. Heliyon, 8(8). https://doi.org/10.1016/j.heliyon.2022.e10251

Morshed, H., Sayeed, M., Mostofa, A., … S. I.-P., & 2012, undefined. (2012). Antithrombolytic and antidiabetic activity of methanolic extract of Paederia foetida. Elsevier, 4(30), 30–33. https://doi.org/10.5530/pj.2012.30.6

Mwangi, R. W., Macharia, J. M., Wagara, I. N., & Bence, R. L. (2021). The medicinal properties of Cassia fistula L: A review. Biomedicine and Pharmacotherapy, 144. https://doi.org/10.1016/j.biopha.2021.112240

Mwangi, R., Macharia, J., … I. W.-B. &, & 2021, undefined. (n.d.). The medicinal properties of Cassia fistula L: A review. Elsevier. Retrieved August 5, 2023, from https://www.sciencedirect.com/science/article/pii/S0753332221010246

Pawar, A., Research, S. K.-I. J. for A., & 2017, undefined. (2012). Uses of Cassia fistula Linn as a medicinal plant. Ijarnd.Com, 1(5), 79. https://www.ijarnd.com/manuscript/uses-cassia-fistula-linn- medicinal-plant/

Pawar, A., Research, S. K.-I. J. for A., & 2017, undefined. (2017). Uses of Cassia fistula Linn as a medicinal plant. Ijarnd.ComAV Pawar, SG KilledarInternational Journal for Advance Research and Development, 2017•ijarnd.Com. https://www.ijarnd.com/manuscript/uses-cassia-fistula-linn-medicinal-plant/

Rahman, F. Bin, Ahmed, S., Noor, P., Rahman, M. M. M., Huq, S. M. A., Akib, M. T. E., & Shohael, A. M. (2020). A comprehensive multi-directional exploration of phytochemicals and bioactivities of flower extracts from Delonix regia (Bojer ex Hook.) Raf., Cassia fistula L. and Lagerstroemia speciosa L. Biochemistry and Biophysics Reports, 24. https://doi.org/10.1016/j.bbrep.2020.100805

Reddy, M. P., Shantha, T. R., Rao, V. R., Shiddamallayya, N., & Dixit, A. K. (2018). PHARMACOGNOSTICAL STANDARDIZATION ON THE ROOTS OF AGNIMANTHA-PREMNA SERRATIFOLIA LINN. Ijpjournal.ComMP Reddy, TR Shantha, VR Rao, N Shiddamallayya, AK Dixitijpjournal.Com, 5(7), 426–430. https://doi.org/10.13040/IJPSR.0975-8232.IJP.5(7).426-30

Res, A. S.-I. J. A. P., & 2013, undefined. (2013). Medicinal properties of Bala (Sida cordifolia Linn. and its species). Core.Ac.Uk, 1(2), 1–9. https://core.ac.uk/download/pdf/333819212.pdf

Rizvi, M., Irshad, M., … G. H.-A. journal of, & 2009, undefined. (2015). Bioefficacies of Cassia fistula: an Indian labrum. Academicjournals.Org, 5(2), 280–289. https://academicjournals.org/article/article1380881495_Moshahid%20et%20al..pdf

Rudrappa Harisha, C., Kumar Prajapati, P., Singh Yadav, S., & Rudrappa, H. C. (2011). Pharmacognostical and physicochemical investigations of Albizia Lebbeck Benth. Leaf. Researchgate.NetSS Yadav, PKP Galib, HC RudrappaInternational Journal of Science Innovations and Discoveries (IJSID), 2011•researchgate.Net, 2011(2), 178–185. https://www.researchgate.net/profile/Galib- Ruknuddin/publication/274706923_Pharmacognostical_and_physico- chemical_investigations_of_Albizia_lebbeck_Benth_Leaf/links/552678410cf2ee9bad77eba1/Pharm acognostical-and-physico-chemical-investigations-of-Albizia-lebbeck-Benth-Leaf.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail

Sartorelli, P., Andrade, S. P., Melhem, M. S. C., Prado, F. O., & Tempone, A. G. (2007). Isolation of antileishmanial sterol from the fruits of Cassia fistula using bioguided fractionation. Phytotherapy Research, 21(7), 644–647. https://doi.org/10.1002/PTR.2131

Seethapathy, G. S., Ganesh, D., Santhosh Kumar, J. U., Senthilkumar, U., Newmaster, S. G., Ragupathy, S., Uma Shaanker, R., & Ravikanth, G. (2015). Assessing product adulteration in natural health products for laxative yielding plants, Cassia, Senna, and Chamaecrista, in Southern India using DNA barcoding. International Journal of Legal Medicine, 129(4), 693–700. https://doi.org/10.1007/S00414-014-1120-Z

Sikri, N., Dhanda, S., & Dalal, S. (2019). Kinetics of urease inhibition by different fractions of Cassia fistula. South African Journal of Botany, 120, 274–279. https://doi.org/10.1016/j.sajb.2018.07.016

Sunil, J. P., Sciences, H. P.-R. J. of R., & 2012, undefined. (2012). Ethnomedicinal herbal recipes from satpura hill ranges of shirpur tahsil, dhule, maharashtra, India. Isca.MeJ Patil Sunil, HM PatilResearch Journal of Recent Sciences, 2012•isca.Me, 1, 333–336. http://www.isca.me/rjrs/archive/v1/iISC-2011/55.ISCA-ISC-2011-3BS-84.pdf

Tanveer, S., Ashiq, K., Bajwa, M., Latif, A., Qayyum, M., & Bajwa, M. A. (2019). A comprehensive review on pharmacological and phytochemical potential of Cassia Fistula Linn: A Magical Herb. Researchgate.Net, 8(6). https://doi.org/10.31032/IJBPAS/2019/8.6.4734

Tari, R., Carmagnola, S., Pagliarulo, M., Balzarini, M., Ballarè, M., Orsello, M., Venezia, L., & Del Piano, M. (2012). Are anthranoid laxatives effective in chronic constipation? Nutrafoods, 11(4), 131–136. https://doi.org/10.1007/S13749-012-0052-9

Wijaya, R., Neumann, G. M., Condron, R., Hughes, A. B., & Polya, G. M. (2000). Defense proteins from seed of Cassia fistula include a lipid transfer protein homologue and a protease inhibitory plant defensin. Plant Science, 159(2), 243–255. https://doi.org/10.1016/S0168-9452(00)00348-4

Yasmeen, G., Hussain, S., Tajammal, A., Mustafa, Z., Sagir, M., Shahid, M., Ibrar, M., Mehr-un-Nisa, Elqahtani, Z. M., & Iqbal, M. (2023). Green synthesis of Cr2O3 nanoparticles by Cassia fistula, their electrochemical and antibacterial potential. Arabian Journal of Chemistry, 16(8). https://doi.org/10.1016/j.arabjc.2023.104912

Yohana Chaerunisaa, A., Susilawati, Y., Muhaimin, M., Milanda, T., Hendriani, R., & Subarnas, A. (2020). Antibacterial activity and subchronic toxicity of Cassia fistula L. barks in rats. Repository.Unja.Ac.Id. https://doi.org/10.1016/j.toxrep.2020.04.013

Zafaryab, M., Singh, M., Moshahid, M., & Rizvi, A. (2012). Comparative Analysis of the Antioxidant Activity of Cassia fistula Extracts. International Journal of Medicinal Chemistry, 2012. https://doi.org/10.1155/2012/157125.