Genetic aspects of type 2 diabetes mellitus associated with chronic heart failure

Abstract

Today, the prevalence of type 2 diabetes mellitus (T2DM) has reached “pandemic” proportions. Diabetes is the most significant problem of modern healthcare, as it is characterized by high disability and mortality. FABP2 plays a key role in the absorption and intracellular transport of dietary long-chain fatty acids. Since glucose and fatty acid metabolism are interrelated phenomena, FABP2 soon became an important candidate gene for T2DM.

The aim of the study was to study the polymorphism of the FABP2 gene in patients with T2DM associated with CHF.

Methods and materials. To achieve this goal, a genetic study was conducted in 125 patients diagnosed with type 2 diabetes with and without CHF, treated in the endocrinology and cardiology departments of clinics of the Andijan State Medical Institute. Testing of the FABP2 rs 1799883 polymorphism was carried out by allele-specific PCR in Real-Time format on a Rotor-Gene Q device ( Quagen , Germany) using a commercial test kit from Syntol LLC (Russia) in accordance with the manufacturer’s instructions.

Results. In patients with type 2 diabetes without CHF, the presence of the allele Thr increased the risk of developing isolated type 2 diabetes by 1.9 times (25.7% versus 15.4%; χ2=3.8; p=0.05; OR=1.9; 95%CI: 0.99 - 3.66 respectively).

Conclusion. A significant relationship was identified between the carriage of an unfavorable allelic variant 54Thr of the FABP2 gene, associated with increased metabolism of fats in the body and the risk of developing type 2 diabetes, but without CHF.