Identification of B- cell and T- cell specific peptide vaccine for Histoplasma capsulatum

Abstract

Histoplasma capsulatum is an environmental dimorphic fungus.  H. capsulatum infections are primarily acquired, and there is no person-to-person transmission with the rare exception of organ transplantation. The objective of this research is to identify a B-cell and T-cell specific peptide vaccine for H. capsulatum by analyzing the outer membrane protein, predicting B-cell and T-cell epitopes, and selecting a candidate peptide vaccine with high homology to the pathogen and strong MHC I-binding potential