EXPERIMENTAL USE OF GLAUCONITE IN THE TREATMENT OF TROPHIC ULCERS IN WHITE RATS

Abstract

Background: The escalating prevalence of chronic non-healing trophic ulcers (TUs) in dermatological practice necessitates innovative therapeutic approaches. This study explores the potential of glauconite, a natural sorbent rich in hydrous aluminosilicate clay minerals, in treating experimentally induced TU in rats. The etiological factors for TU include endocrinopathy, vascular diseases, and neurological disorders, posing a significant challenge for conventional treatments.

Methods: Twenty outbred rats were subjected to a TU model by applying 70% acetic acid. The animals were divided into control (Group I) and treatment (Group II) groups, with the latter receiving glauconite powder. Clinical and histological examinations, including microscopic analyses, were conducted at various intervals to evaluate the therapeutic efficacy of glauconite.

Results: Glauconite application exhibited notable effects, accelerating lesion resorption, epithelization, and fibroblast activation. Histological observations revealed improved tissue regeneration, reduced inflammation, and enhanced cellular reactions in glauconite-treated rats. Comparative analysis indicated statistically significant differences in crust development, epithelization, and purulent-inflammatory resorption compared to the control group.

Conclusion: Glauconite, a hydrous aluminosilicate clay mineral, demonstrated promising therapeutic potential in the experimental treatment of trophic ulcers. The accelerated healing process, characterized by enhanced cellular reactions and reduced inflammation, suggests the feasibility of glauconite as a novel therapeutic agent for dermatological applications, offering an alternative approach to conventional treatments for chronic skin lesions.