The Mechanism of Platelet-rich Plasma (PRP) Improving Sciatic Nerve Regeneration via NGF Mechanism: Clinical Applications of Allogenic PRP

Abstract

Platelet-rich plasma (PRP) may treat nerve injury due to its regeneration properties. Most studies have focused on autologous PRP, leaving unverified the efficacy and safety of allogenic PRP. This article investigates the nerve-regeneration capacity of allogenic PRP extracted from Wistar rats. Using injections, we evaluate its effects on nerve regeneration and neurotropic factor expression, specifically NGF and S100B. PRP containing exogenous neurotrophic growth factors stimulates NGF expression and nerve regeneration. PRP may also modify the presentation of S100B and decrease inflammation, thereby accelerating neuron regeneration. These findings shed light on the clinical applications of allogenic PRP and the mechanisms of sciatic nerve regeneration. This review of the literature emphasizes the need for more accessible and scalable treatments for nerve injury. Innovative is the study's concentration on allogenic PRP as a source of neurotrophic factors. This article explores the effects of allogenic PRP on nerve regeneration, NGF, and S100B expression. Compared to controls, allogenic PRP significantly enhances nerve regeneration. Treatment with PRP increases NGF expression, demonstrating its significance in nerve healing. By modulating S100B expression and reducing inflammation, allogenic PRP may hasten nerve regeneration. These results suggest that allogenic PRP may be able to repair nerve damage. The findings are discussed in the context of regenerative medicine and the need for autologous PRP alternatives. As study limitations, the animal model and the absence of human trials are mentioned. Consideration is given to the clinical implications, benefits, and risks of allogenic PRP. In conclusion, allogenic PRP may promote nerve regeneration. The findings demonstrate the NGF-boosting and nerve-repair capabilities of PRP. Allogenic PRP may alter the expression of S100B and reduce inflammation, thereby accelerating nerve regeneration. These findings enhance our understanding of allogenic PRP and its clinical applications, thereby creating new avenues for treating nerve injuries, specifically sciatic nerve lesions. Allogenic PRP requires clinical trials to demonstrate its safety and effectiveness.