Assessment of The Level of Neopterin in Oral Fluid and Blood Plasma in Patients with Rheumatoid Arthritis

Abstract

It is known that neopterin is a metabolite of nucleic bases, similar in structure to a folic acid molecule (Lazarchik I.V. et al., 2016). It is synthesized mainly by cells of the macrophage-monocyte pool under the influence of gamma interferon and reflects the synthesis of this cytokine, which plays a significant role in the immune response (Domínguez-Pérez R.A. et al., 2017). It is the synthesis of gamma interferon that distinguishes most cytotoxic cellular immune reactions in the course of an antiviral or antitumor immune response (Patel B.P. et al., 2007). And also, in autoimmune diseases – and specific immune inflammation Dudina K.R. et al., 2017).