LIPID PEROXIDATION AND THE ANTIOXIDANT SYSTEM IN ACUTE CORONARY SYNDROME

Abstract

The involvement of reactive oxygen species in metabolism under conditions of insufficiency (depletion) of antioxidant activity system AOS enzymes has a direct damaging effect on cardiomyocytes, activates the procoagulant system, accelerates the degradation of endothelial NO, which ensures vasodilation. In patients with ACS (acute coronary syndrome) there is a significant increase in LPO (Lipid peroxidation) activity and a decrease in AOS, which is accompanied by oxidative modification of lipids in platelet membranes and blood plasma.