Utilizing Natural Mucoadhesive Polymers for Development of Nanoparticle Based Cilnidipine Buccal Films

Abstract

The less oral bioavailability of Cilnidipine is primarily due to low solubility leads to reduced therapeutic efficacy. The study aimed to develop mucoadhesive buccal films to increase the bioavailability resulting in improved efficacy of this pooly soluble drug trough the buccal mucosa for the treatment of hypertension. Buccal films of Cilnidipine nanoparticles were developed by using different concentration of polymers such as HPMS K4M, HPMC K15M and Carbopol 934 by solvent casting technique. The developed films were characterized for the surface texture, thickness, surface pH, folding endurance, swelling index, content uniformity, mucoadhesive strength, moisture loss, moisture absorption, drug release, ex-vivo drug permeation and stability studies. F9 formulation was optimized as best formulation based on the physico chemical parameters, in vitro dissolution and ex-vivo permeation studies. The result indicates that the drug releases from the buccal films are slow and prolonged over the period of 12 h. There was no significance changes were observed during the stability studies indicates that, the prepared buccal films are stable. Hence, mucoadhesive buccal films can be used as an alternative particularly in the bed time with improved absorption of the dug through buccal mucosa, resulting in better bioavailability and therapeutic efficacy.