The Effect of Different Concentrations of Bee Venom on Kidney Tissue of Albino Male Rats Rattus

Abstract

In this study, 60 males of albino rats (Rattus rattus) were tested to study the effect of BV on kidney tissue at two doses of 10 and 40 µg/kg and two times after 10 and 15 days. The sample included 40 rats divided into two groups; 20 rats for each group. These groups were injected intraperitoneally according to the mentioned periods and were considered as a control group. The results exhibited renal tubule dilation and slight atrophy of glomerular tuft in the kidneys of rats treated with 10 µg/kg for 10 days compared to kidneys in the control treatment. Furthermore, 10 µg/kg treatment for 15 days has caused renal tubule dilation and degeneration with cytoplasmic vacuolation. Our findings also showed a slight atrophy of the glomerular tuft as well as a reduction in the number of glomeruli in this subcapsular area. The results also indicate regeneration of kidney tubules in rats given 40 µg/kg for 10 days. Meanwhile,  sections of the kidney for rats that were given 40 µg/kg for 15 days exhibited   a slight atrophy of glomerular tuft hypertrophied tubular epithelial cells.