The Effect of Some Animal and Plant Proteins on uric acid index in Rats with Acute Renal Failure

Abstract

Kidney diseases are a public health problem all over the world. From recent studies it has been found that a low-protein diet as part of diet therapy has beneficial effects that slow the progression of chronic kidney disease. So, this study was carried out to investigate the uric acid index of some animal protein (Beef, eggs, kidney) and plant protein (mushroom, yellow lentils, lupine) in rats with induced-acute renal failure (ARF). Forty rats were divided into 8 groups (n=5) in each group. The first group of rats was fed on basal diet. The other rats were injected with one dose of 50% glycerol (10 ml/kg B.Wt.) in their hind limbs to induce ARF, these rats were divided into 7 subgroups, as follows: Subgroup (1): Rats with ARF were fed on basal diet supplemented with 150 gm/kg casein as positive control group (+Ve). From subgroups (2 : 7) rats were fed on the basal diet supplemented with 150 gm/kg from dried beef, eggs, kidney, mushroom, yellow lentils, lupine, respectively for 4 weeks. The treated groups with either animal or plant proteins had a significant decrease (P<0.05) in the level of kidney functions as well as lowering the mean values of phosphorous, sodium and potassium. The level of serum albumin and total protein were significantly (P<0.05) increased as compared to the +ve control group. It could be concluded that a diet containing animal protein (beef, eggs, kidney) or plant protein (mushroom, yellow lentils, lupine) may be used as a part of diet therapy to slow the progression of kidney disease and improve the kidney functions.