A Histopathological Study of the Therapeutic Role of Kisspeptin-10 Against Cadmium Chloride Toxicity in Rats

Abstract

Kisspeptin is originally a metastasis suppressor. Currently, post preliminary discovery, the crucial physiology of kisspeptin appeared among several biological function in the living body such as supporting the reproductive system, regulation the metabolism, improvement the cardiac muscle action and smooth muscle of blood vessels. Moreover, Kisspeptin play an important role as a neurotransmitter through the Kisspeptin receptor. This study is designed to examine the anti-toxic role of Kisspeptin in some vital organs including the liver, spleen, and kidney. Kisspeptin is demonstrated as a detoxification agent via the elimination of toxicity of cadmium chloride to some organs of living rats such as the liver, spleen, and kidney. Direct negative effects of Kisspeptin on these organs have only been recognized. This study attempts to explain this role during the examination of histopathological changes in the case of cadmium chloride toxicity and the effect of Kisspeptin in reducing or elevating the toxicity after its administration in both 20 and 40 nanomolar / animal doses. Arguments and recent boundaries in the field, as well as areas of coming research related to kisspeptin’s varied function array, should underline.