The Effect of Ursolic Acid and Hyperinsulinemia on the Liver and Kidney Function of Alloxan-Induced Diabetic Male Rabbits

Abstract

The study aimed to examine the effect of extracted and standard ursolic acid in addition to hyperinsulinemia compared to vitamin B complex on the liver and kidney function of alloxan-induced diabetic male rabbits. The liver and kidney functions were determined and analyzed by one–way of a NOVA at variance software at a P-Value of 0.05. The result showed a significant decrease in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and uric acid values in the groups treated with standard and extraction ursolic acid(UA) compared to the diabetic group. The rabbit group that was treated with vitamin B complex recorded a significant decrease in the three liver enzymes, uric acid, and creatinine values than the diabetic group. In addition, the rabbit group that was treated with hyperinsulinemia recorded a significant increase in aspartate aminotransferase (AST) and creatinine values than the diabetic rabbit group. While the histological results in the groups treated with standard and extraction ursolic acid had a clear ameliorative effect in liver and kidney function tests better than hyperinsulinemia, also vitamin B complex caused some good effects.