The Role of Hla Genes in Immune Response, Disease Susceptibility, and Social Behaviours: A Comprehensive Review

Abstract

Major Histocompatibility Complexes (MHC), which assist to code for proteins that distinguish between self and non-self, are significantly influenced by the Human Leukocyte Antigen (HLA) genes. Particularly important in the suppression of immune response are the HLA genes. The bulk of the genes in the MHC region shows considerable variation. The two most important functions of HLA molecules are selection of T cell accumulation and the formation and control of immunological responses. The causes of HLA-G gene-associated illnesses and the underlying mechanisms are still up for dispute. The HLA-G gene has an impact on social behaviour as well. Numerous polymorphisms have been connected to heightened susceptibility to the beginning of autoimmune illnesses as well as heightened disease severity. The lifetime of some HLA genes is shorter.Genetic background, environmental circumstances, and certain polymorphisms have been linked to increased illness severity. certain HLA genes have shorter life spans than others, and vice versa. The major functional elements of HLA-G in both normal and autoimmune disorders are summarized in this study.