Pharmacological Investigation of Antioxidants and Antidiabetic Activity of Vitex Trifolia Bark In Diabetic Zebrafish Model

Abstract

Both diabetes and obesity have now been deemed global epidemics. Scientists coined "diabesity", to describe this relationship, as both obesity and diabetes are on the rise. Obesity increases the risk of heart disease, type 2 diabetes, cancer, and many other diseases. Both diabetes and obesity are complex illnesses that can be influenced both by hereditary factors and environmental ones. In order to develop pharmacological or surgical treatment for obesity and diabetes we need more research. It is therefore essential that animal models be used to better understand diabetes or obesity, and to develop effective treatments. Zebrafish are a good model for metabolic disease research due to their functional conservatism in terms of lipid metabolism and adipose tissue, pancreas structures, glucose homeostasis, etc. It is well suited to finding new ways of treating and preventing human diseases such as diabetes. The review examines both the benefits and drawbacks of using the zebrafish model for studying the diseases associated with diabetes and obesity. This review focuses on studies which have used zebrafish to model these diseases.