Neuro-Protective Effect of Ethanolic Extract of Trombidium Grandissimum Koch Against Aluminium Chloride (Alcl3) Induced Neurotoxicity in Albino Rats

Abstract

The current goal of this investigation is to assess the ethanolic extract of T. grandissimum (EETG) against AlCl₃-initiated neurotoxicity, where AlCl3 (100 mg/kg/p.o) is administered for 42 days by provoking oxidative stress followed by neurotoxicity. The evaluation of behavioural parameters such as locomotor activity, elevated plus maze, and motor incoordination, as well as biochemical parameters such as reduced glutathione, lipid peroxidation, Superoxide dismutase (SOD), Catalase (CAT), total Protein, and Acetylcholinesterase in the brain, was performed. According to the study report, behavioural changes such as dropped locomotor movements, enhanced transfer latency, and muscle weakness were often noted. Significant rising of lipid peroxides and AChE activity in rat brain tissue was observed, and activity of antioxidant enzymes like SOD, Catalase, and Reduced Glutathione decreased substantially in alcl3 treated rats compared to control, whereas EETG at both dose and standard treated rats showed a significant reduction in LPO, AChE activity and significant elevation in SOD, CAT, and GSH in brain tissues compared to AlCl3 treated rats. The findings are further supported by histopathology of the brain. This is due to the extract's enormous amount of bioactive components. Through in-silico analysis, isolation, and characterisation, future research will be required to pinpoint the chemical component responsible for the extract's observed biological effect.