Antiasthmatic Efficacy Of Ethanolic Leaf Extract Of Fagonia Arabica Linn On Isolated Guinea Pig Tracheal Chain Preparation
DOI:
https://doi.org/10.53555/jaz.v43i1.5054Keywords:
acetylcholine, aminophylline, Broncho protection, histamine, Fagonia Arabica LinnAbstract
Aim and objective: The study was aimed to investigate anti-asthmatic activities of ethanolic extract of Fagonia Arabica by in vitro models. Traditionally, plants have been reported to be antiasthmatic but not evaluated, so the objective is to perform it.
Materials and Methods: Acute toxicity studies of Fagonia Arabica Linn were performed. Guinea pigs were screened out and divided into control, standard, and FAEE-treated groups. Anti-asthmatic activity of FAEE was assessed by in vitro guinea pig tracheal chain method.
Results: The antiasthmatic activity of the extracts 10, 20, 30, 40, and 50 µg/ml was evaluated in guinea pig trachea chain-isolated preparations by using standard drugs Acetylcholine and histamine, respectively. The extract pointed reserved all the reactions produced by the inflammatory intermediaries used, and extreme significant anti-asthmatic activity was observed at the doses of 30 µg/ml.
Summary: Preliminary phytochemical analysis showed plants contain alkaloids, flavonoids, terpenoids, saponins, tannins, coumarins, sterols, and glycosides in different polar and nonpolar extracts of plant material. Ethanolic extract of F.A. Leaves show antiasthmatic activity in an in vitro model.
Conclusion: The results of the study exposed the anti-asthmatic activities of F. Arabica, which provides its further consequence for the treatment of cough variant asthma.
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