Screening Of Withania Coagulans Fruit For Antimicrobial And Antidiabetic Property
DOI:
https://doi.org/10.53555/jaz.v43i1.5014Keywords:
Withania coagulans, Fruit, Antimicrobial, AntidiabeticAbstract
Various pharmaceutical preparations used to treat the microbial infections and diabetic problems may lead to hazardous side effects. Hence there is a need to find new ways for developing safe drugs to deal with the increasing complications caused by synthetic drugs. In the traditional health care system many plants are known to have therapeutic history. This property not only varies between species but also on different parts of the same plant. The fruit of the plant Withania coagulans used for the research work was collected from the market in Bengaluru. The crude extract of the sample was prepared by using methanol as a solvent. Antimicrobial analysis of the extract was studied by well diffusion method using the test organisms Escherichia coli, Staphylococcus aureus and Candida albicans. a-Glucosidase inhibition assay was considered for the analysis of antidiabetic property of the sample. Results of the study reveal that W. coagulans fruit is an effective and alternative therapeutic with antimicrobial and antidiabetic property.
Downloads
References
1. Murtaza H., Ayesha Z., Irum S., Fan L., Shahbaz Gul H., Tuba T., Sadaf Z., Tauseef M., Faisal I. & Xugang S. 2020.Fractionation of biomolecules in Withania coagulans extract for bioreductive nanoparticle synthesis, antifungal and biofilm activity. Molecules, 25(15): 3478. https://doi: 10.3390/molecules25153478
2. Shahab M., Asma B., Kiran F., Neha F. & Kashif A. 2018. Antimicrobial screening of Withania coagulans and Nigella sativa against clinical skin infection isolates. International Journal of Advances in Science Engineering and Technology,6; 3 (1): 53-56. https://www.researchgate. net/publication/331222082
3. Upadhyay B. M., & Vandana Gupta. 2011. A clinical study on the effect of Rishyagandha (Withania coagulans) in the management of prameha (Type II diabetes mellitus). Ayu, 32 (4): 507-511. doi: 10.4103/0974-8520.96124
4. Hemalatha V. & Vegasini N. 2018. Effect of supplementation of Withania coagulans fruit on the fasting plasma glucose levels of type 2 diabetic subjects. Asian journal of pharmaceutical and clinical research, 11 (12): 448-451. doi: http://dx.doi.org/10.22159/ajpcr.2018.v11i12.27433
5. Daou M, Elnaker N. A., Ochsenkuhn M. A., Amin S. A., Yousef A. F., & Yousef L. F. 2022. In vitro α glucosidase inhibitory activity of Tamarix nilotica shoot extracts and fractions. Plos One, 17 (3): e0264969. https://doi.org/10.1371/journal. pone.0264969
6. Sampathkumar K., Riyajan S. A., Tan, C. K., Demokritou P., Chudapongse N., & Loo, S. C. J. 2019. Small-intestine-specific delivery of antidiabetic extracts from Withania coagulans using polysaccharide-based enteric-coated nanoparticles. ACS Omega, 4, (7): 12049–12057. https://doi.org/10.1021/acsomega.9b00823
7. Rageeb M. D., Usman M. D., & Bhat N. G. 2023. Evaluation of antidiabetic activity of Withania coagulans Dunal. International Journal of Pharmaceutical Sciences and Research, 14(2): 981-987. doi: 10.13040/IJPSR.0975-8232.14(2).981-87
8. Prashik K., Pratiksha K., Prachi K., Manavi Kajave, & Snehal K. 2022. Phytochemical screening and evaluation of antimicrobial activity of Withania coagulans. International Journal of Pharmaceutical Research and Applications, 7(5): pp: 998-1005. doi: 10.35629/7781-07059981005
9. Sastri K N., Caturvedi R P., & Sashtri R P. 1998. editors Sutrasthana. Reprint. 5/2. 1 and 2. Varanasi: Caukhambha Bharati Academy; Charaka Samhita with Vidyotini Hindi Commentary; p. 72. [Google Scholar]
10. Shukla K., Dikshit P., Shukla R., & Gambhir J. K. 2012. The aqueous extract of Withania coagulans fruit partially reverses Nicotinamide/Streptozotocin-induced diabetes mellitus in rats. Journal of medicinal food, 15 (8), 718–725. doi: 10.1089/jmf.2011.1829
11. Prakash Chandra Gupta. 2012. Withania coagulans Dunal- An overview. International J. of Pharmaceutical Sciences Review and Research, 2 (12): 68-71.
12. Maurya J., & Akanksha J. 2010. Chemistry and pharmacology of Withania coagulans: an ayurvedic remedy. Journal Pharma Pharmacol, 62: 153-160. doi: 10.1211/jpp.62.02.0001
13. Jaiswal D, Rai P. K., & Watal G. 2010. Hypoglycemic and antidiabetic effects of Withania coagulans fruit ethanolic extract in normal and streptozotocin-induced diabetic rats. Journal of Food Biochemistry, 34 (4):764–778. doi:10.1111/j.1745-4514.2009.00314.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Mohan Kumar H.M., Swechchha K.M., Rajeev Ramachandra Kolgi , Shankara S.
This work is licensed under a Creative Commons Attribution 4.0 International License.
