In Vivo Antidiabetic Potential Of Niosome Naringin Nanoconjugate In Streptozotocin Induced Diabetic Mice
DOI:
https://doi.org/10.53555/jaz.v45i4.4521Keywords:
diabetes, polyphenols, nanotechnology, biochemical, toxicity, animal modelAbstract
Diabetes mellitus remains a significant global health concern, necessitating the exploration of novel therapeutic strategies. In this study, we investigated the in vivo antidiabetic potential of Niosome Naringin Nanoconjugate, a nanoformulation designed to enhance the bioavailability and therapeutic efficacy of naringin, a naturally occurring flavonoid with reported antidiabetic properties. Male Wistar rats were induced with diabetes mellitus using streptozotocin and treated with Niosome Naringin Nanoconjugate orally for a specified duration. The effects of the nanoconjugate on glucose tolerance, fasting blood glucose levels, insulin resistance, and lipid profile were evaluated. Our results demonstrate that Niosome Naringin Nanoconjugate significantly improved glucose tolerance, reduced fasting blood glucose levels, and ameliorated insulin resistance compared to diabetic control groups. Additionally, the nanoconjugate exhibited enhanced bioavailability and prolonged circulation time, suggesting potential for sustained therapeutic effects. These findings highlight the promising antidiabetic efficacy of Niosome Naringin Nanoconjugate and underscore its potential as a novel therapeutic agent for the management of diabetes mellitus. Further investigations, including long-term safety assessments and clinical trials, are warranted to fully elucidate its clinical applicability. Overall, this study contributes valuable insights into the development of innovative nanomedicine approaches for diabetes management, with Niosome Naringin Nanoconjugate emerging as a promising candidate for future therapeutic interventions.
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