Development And Characterization Of Colon Targeted Microspheres For Intestinal Infection
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Abstract
Various colon-targeted oral delivery systems have been explored so far
to treat colorectal diseases, including timed-release systems, prodrugs,
pH-based polymer coatings, and microflora-triggered systems. The
polysaccharide-based colon-targeted delivery system has been found to
be quite promising as polysaccharides remain unaffected by gastric as
well as upper intestine milieu and are only digested by colonic bacteria
upon reaching the colon. The metronidazole containing microsphere has
other characterization is in the term of percentage yield, entrapment
efficiency, FT-IR and the in-vitro drug release. The In-vitro release
pattern of metronidazole studied in colonic environment as 900ml media
using USP dissolution apparatus II. The cumulative release rate of
prepared microspheres was followed by a sustained release and fitted for
classic Higuchi kinetic model. The results showed that chitosan
microspheres are thought to have the potential to maintain drug
concentration within target ranges for a long time, decreasing side effects
caused by concentration fluctuation, ensuring the efficiency of treatment
and improving patient compliance by reducing dosing frequency.
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