Evaluation Of Antidiarrhoeal Activity Of Ethanolic Leaf Extract Of Woodfordia Fruticose And Rubus Ellipticus In Swiss Albino Mice

Abstract

One of the main preventable causes of death in developing nations is diarrhoea. According to reports, the leaves of Woodfordia fruticose and Rubus ellipticus have traditionally been employed as an antidiarrheal remedy. The current study sought to assess the pharmacological activity of an ethanolic extract of Woodfordia fruticose and Rubus ellipticus leaf in the treatment of diarrhoea. The extract was utilized to treat castor oil-induced diarrhea in mice. The extracts were given to mice orally at dosages of 100, 200, and 400 mg/kg bodyweight, with loperamide serving as a typical diarrhea treatment. The results demonstrated % inhibiting diarrhoea with values of no detectable, 43.68%, 82.98%, and 71.42% at 100, 200, and 400 mg/kg bodyweight levels of dose of the extract and loperamide, respectively, as compared to the negative control. At a dose of 400 mg/kg bodyweight, the extract has a stronger antidiarrheal effect than loperamide. In conclusion, an ethanolic extract of Woodfordia fruticose and Rubus ellipticus leaves shows anti-diarrheal activity, supporting use this plant as an antidiarrheal in traditional medicine.