SYNTHESIS, CHARACTERIZATION AND ASSESMENT THE ANTIBACTERIAL EFFICACCY OF SCHIFF BASED COMPOUNDS GENRATED FROM ISATIN

Abstract

Indole-2,3-dione (isatin) and its derivative have been recated with 2 and 4 substituted 1,3,4-thiadiazole derivative form Schiff bases of these compounds were synthesized in the presence of alcohol. Their chemical structure have been confirmed by mean of their IR and 1HNMR. Antimicrobial screening of synthesized compounds was done by well diffusion method against 4 pathogenic becteria and 2 pathogenic fungi. Amongst the tested compounds 5-fluoro-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]-1,3-dihydro-2H-indol-2-one, 5-methyl-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]-1,3-dihydro-2H-indol-2-one,and 5-nitro-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]-1,3-dihydro-2H-indol-2-one exhibit significant antibacterial activity and 5-chloro-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]-1,3-dihydro-2H-indol-2-one, 5-fluoro-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]-1,3-dihydro-2H-indol-2-one and 5-methyl-3-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)imino]-1,3-dihydro-2H-indol-2-one  showed favourable antifungal activity.