Analytical Method Development and Validation of Iron, Arsenic, Cadmium, Mercury and Lead Content in Sunset Yellow by Inductively Coupled Plasma Mass Spectrometry (Icp-Ms)

Abstract

A method for determining the iron, arsenic, cadmium, mercury, and lead content in Sunset Yellow by ICP-MS was developed, verified, and implemented for routine ICP-MS analysis. Inductively coupled plasma mass spectrometry (ICP-MS) is a good instrument for determining the basic composition of numerous substances. Iron, arsenic, cadmium, mercury, and lead metal as defined in USP (233) linearity, method precision, accuracy, robustness, and ruggedness factors were taken into account and analysed for method validation in this work. The recovery rates of iron, arsenic, cadmium, mercury, and lead metals ranged between 92.0% and 101.4%. The detection limits of all elements investigated demonstrated the procedure's suitability for routine analyses. To summarize, the provided analytical processes can be used to measure the mass fractions of iron, arsenic, cadmium, mercury, and lead components in Sunset Yellow samples.