Contribution of Tumor Necrosis Factor Alpha Polymorphic Gene (rs1800629) to the Mechanisms of Immune Microthrombocytosis and Immune Thrombocytopenia in Adults in Uzbekistan

Abstract

We studied the association of the genetic polymorphism rs1800629 TNFα in the development of immune microthrombocytosis (Shenlein-Genoch purpura) and immune thrombocytopenia in adults of Uzbek nationality. The rs1800629 gene TNFα polymorphism was assessed using DNA samples obtained from peripheral blood through standard PCR analysis. The research results showed a significant difference in the distribution of allele A and genotype G/A of the TNFα gene (rs1800629) among patients with immune microthrombocytosis (allele A: χ2=4.89; P=0.027; OR=2.53; 95% CI 1.09-5.89 and genotype G/A: χ2=5.58; P=0.018; OR=2.92; 95% CI 1.18-7.26) and immune thrombocytopenia (allele A: χ2=5.05; P=0.024; OR=2.44; 95% CI: 1.10-5.40 and genotype G/A: OR=2.37; χ2=3.86; P=0.049; 95% CI: 1.99-5.67) during the active phase of the disease compared to the control group. This suggests the potential involvement of this polymorphism in the development of immune microthrombocytosis and immune thrombocytopenia.