The Effect of Flavonoid from Extract of Phaleria Macrocarpa on Levels Il-2, Il-17a and Il-33 in Endometriosis Mice

Abstract

Endometriosis is a inflamatory disease especially in the state of reproductive age. Phaleria macrocarpa is a plant that has a population in Papua, Irian Jaya. Endometriosis therapies available have still many weakness, including being expensive, only relieving pain, and continuous treatment to prevent endometriosis from recurring. The fruit and seeds of the Phaleria macrocarpa have a wide range of important biological activities in the form of extracts such as antimicrobial, anti-inflammatory, and antioxidant activities. This aim of this was to analyze the effect of flavonoid from extract of phaleria macrocarpa on IL-2, IL-17A, and IL-33 levels in endometriosis mice. This research is using total of 40 female mice (Mus musculus) model endometriosis were grouped into 8 groups, including of healthy mice (without any treatment), the endometriosis group, and the endometriosis group treated flavonoids of Phaleria macrocarpa with dose of 3.75 mg/day; 7.5 mg/day; 11.2 mg/day; 15 mg/day. The level of IL-2, IL-17A, IL-33 were measured using the ELISA method. There was an increase in IL-2, IL-33, and IL17A levels in mice model of endometriosis. Flavonoid of Phaleria macrocarpa can reduce levels of proinflammatory cytokines such as IL-2, IL-33, and IL17A.