A study on water intake and food consumption in animals treated with Thyroxine followed by Bauhinia Purpurea and Withania Somnifera - Original Research
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Abstract
Background: There has been a tremendous range of interest in drugs obtained from medicinal plants that are believed to be safer with significant efficacy in the treatment of thyroid disorders Objective: to observe the water intake and food consumption in animals treated with Thyroxine followed by Bauhinia Purpurea and Withania Somnifera. Materials and Methods: A total of 30 adult female Albino rats of Wistar Strain weighing 150-230 grams were utilized for the present study. The animals were maintained and the protocol was approved by the Institutional Animal Ethical Committee (No.878/ac/05/CPCSEA/10/22) from Raghavendra Institute of Pharmaceutical Education & Research (RIPER), Anantapur, Andhra Pradesh. The animals were divided into 5 groups and each group consisted of 6 animals in our study Results: The mean water intake rate was significantly decreased (25.94+0.42) in the rats treated with thyroxine (0.5 mg/kg b.w) followed by Bauhinia purpurea (150mg) and Withania somnifera (1000mg) when compared control group was 29.44+0.27. The food consumption rate was significantly increased in the rats treated with Thyroxine(0.5 mg/kg b.w) 21.33+1.71 when compared to the control group in our study Conclusion: The animals treated with thyroxine alone showed increased food consumption compared with other experimental and control groups, whereas water intake was significantly higher in control animals than other experimental groups.
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References
K Boelaert , J A Franklyn: Thyroid hormone in health and disease. Boelaert K., Franklyn J.A. Thyroid hormone in health and disease. J. Endocrinol. 2005;187:1-15. . 2005, 187:1-15. 10.1677/joe.1.06131
V. Bharthi, N.P. Kavya, M.N. Shubhashree, S. Bhat: Herbal approach to management of thyroid disease-a review. Bharthi V, Kavya N, Shubhashree MN, Bhat S. Herbal approach to management of thyroid disease – a review. J Ayu Herb Med 2017;3(1):48-52.. 2017, 3:48-52.
Z. Shokri, M. Khoshbin, A. Koohpayeh, N. Abbasi, F. Bahmani, M. Rafieian-Kopaei, F. Beyranvand: Thyroid diseases: Pathophysiology and new hopes in treatment with medicinal plants and natural antioxidants.2018, 12:473-482. 10.22377/ijgp.v12i03.2007
Kumar T and Chandrashekar KS. Bauhinia purpurea Linn: A Review of its Ethnobotany, Phytochemical andPharmacological Profile. Research Journal of Medicinal Plant. 2011:420-431.
Sharma AK, Basu I, Singh S: Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo Controlled Trial. J Altern Complement Med. 2018, 24:243-248. 10.1089/acm.2017.0183
Vijayan E, McCann SM. 1977: Suppression of feeding and drinking activity in rats following intraventricularinjection of thyrotropin releasing hormone (TRH). 11-100. 10.1210/endo-100-6-1727
Suzuki T, Kohno H, Sakurada T, Tadano T, Kisara K. 1982: Intracranial injection of thyrotropin releasing hormone (TRH) suppresses starvation-induced feeding and drinking in rats. Pharmacology Biochemistry and Behavior. 17:249-253. 10.1016/0091-3057(82)90078-8
Lin M, Chu P, Leu S. 1983: Effects of TSH, TRH, LH and LHRH on thermoregulation and food and water intake in the rat. Neuroendocrinology. 37:206-211. 10.1159/000123544
S. Ishii, J. Kamegai, H. Tamura, T. Shimizu, H. Sugihara, and S: Oikawa, “Triiodothyronine (T3) stimulates food intake via enhanced hypothalamic AMP-activated kinase activity,”. Regulatory Peptides, vol. 151, no.1-3, pp. 164-169. 2008, 10.1016/j.regpep.2008.07.007
W. M. Kong, N. M. Martin, K. L. Smith.: Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus independent of changes in energy expenditure,. Endocrinology, vol. 145, no. 11.5252:5258. 10.1210/en.2004-0545
S. Alton and B. P. O’Malley: Dietary intake in thyrotoxicosis before and after adequate carbimazole therapy; The impact of dietary advice,. Clinical Endocrinology, vol. 23, no. 5. pp.:517-520. 10.1111/j.1365-2265.1985.tb01111.x
H. Pijl, P. H. E. M. De Meijer, J. Langius.: Food choice in hyperthyroidism: potential influence of the autonomic nervous system and brain serotonin precursor availability,. Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 12, pp. 5848-5853. 2001, 10.1210/jcem.86.12.8112
S. Ishii, J. Kamegai, H. Tamura, T. Shimizu, H. Sugihara, and S: Oikawa, “Hypothalamic neuropeptide Y/Y1receptor pathway activated by a reduction in circulating leptin, but not by an increase in circulating ghrelin,contributes to hyperphagia associated with triiodothyronine-induced thyrotoxicosis,”. Neuroendocrinology,vol. 78, no. 6. 321:330. 10.1159/000074885
L. P. Klieverik, C. P. Coomans, E. Endert : Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo,. Endocrinology, vol. 12:5639-5648. 10.1210/en.2009-0297