Anti-Diabetic Study of Flower Extract of Eugenia Jambolona In Rats
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Abstract
We are learning more about the role that integrated medicine plays in treating metabolic illnesses. This is partially based on an abundance of scientific data regarding therapeutic herbs, including those with promise to treat diabetes, and in part on the WHO's and other governmental organizations’ support for the practise. The anti-diabetic effect of number of flowers of Eugenia jambolana (EJA) was evaluated in the current study on streptozotocin-induced diabetic rats. The The study's primary goal was to look into the potential antidiabetic effects of sub-chronic oral administration of E. jambolana flowers infusion in rats with STZ-induced diabetes. In diabetic experimental rats, the floral extract considerably reduced blood sugar and cholesterol levels when given 400 mg/kg of body weight are the dosage. It also increased liver glycogen and total protein levels, enhanced reduced Hb1AC, serum level, and antioxidant levels, as well as impaired glucose tolerance. Additionally, it raised liver glycogen and total protein levels as well as glucose tolerance. A common hypoglycemic medication called Glibenclamide was used to compare the hypoglycemic efficacy.The preclinical investigation's results could be useful for phase 2 clinical studies that aim to reduce the morbidity and mortality of diabetes mellitus exacerbated by drug-induced hypoglycemia by implementing integrated medicine.
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References
Baliga, M. S., Bhat, H. P., Baliga, B. R. V., Wilson, R., &Palatty, P. L. (2011). Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam.(black plum): a review. Food Research International, 44(7), 1776-1789.
Ayyanar, M., Subash-Babu, P., &Ignacimuthu, S. (2013). Syzygium cumini (L.) Skeels., a novel therapeutic agent for diabetes: folk medicinal and pharmacological evidences. Complementary Therapies in Medicine, 21(3), 232-243.
Arumugam, G., Manjula, P., &Paari, N. (2013). A review: Anti diabetic medicinal plants used for diabetes mellitus. Journal of Acute Disease, 2(3), 196-200.
Ayyanar, M., &Subash-Babu, P. (2012). Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses. Asian Pacific journal of tropical biomedicine, 2(3), 240-246.
Yadav, M., Yadav, A., Kumar, S., &Yadav, J. P. (2016). Spatial and seasonal influences on culturableendophyticmycobiota associated with different tissues of Eugenia jambolana Lam. and their antibacterial activity against MDR strains. BMC microbiology, 16(1), 1-12.
Patil, R., Patil, R., Ahirwar, B., &Ahirwar, D. (2011). Current status of Indian medicinal plants with antidiabetic potential: a review. Asian Pacific Journal of Tropical Biomedicine, 1(2), S291-S298.
Dametto, A. C., Agustoni, D., Moreira, T. F., Plaza, C. V., Prieto, A. M., Silva, T. G., ... &Soares, C. P. (2017). Chemical composition and in vitro chemoprevention assessment of Eugenia jambolana Lam.(Myrtaceae) fruits and flowers. Journal of Functional Foods, 36, 490-502.
Sangeetha, S., Archit, R., &SathiaVelu, A. (2014). Phytochemical testing, antioxidant activity, HPTLC and FTIR analysis of antidiabetic plants Nigella sativa, Eugenia jambolana, Andrographispaniculata and Gymnemasylvestre. J. Biotechnol, 9, 1-9.
Jayaraju, K. J., &Ishaq, B. M. (2021). Evaluation of antidiabetic activity of a novel polyherbalpreparationagainst streptozotocin induced diabetes rat model. Journal of Pharmaceutical Research International, 33(26A), 42-54.
Akbar, S., & Akbar, S. (2020). Syzygium cumini (L.) Skeels (Myrtaceae) (Syns.: Eugenia cumini (L.) Druce; E. jambolana Lam.). Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications, 1715-1728.
Ogato, D. M., Mauti, E. M., Mauti, G. O., Kowanga, D. K., &Ouno, G. A. (2015). Antimicrobial activity of Eugenia jambolana seeds against foodborne isolates.
Singh, A., &Waldia, A. (2015). Acute toxicity study and antidiabetic activity of poly herbal hydro ethanolic extracts [phe-a, b, c, d and e] of individual plants in different ratios.
Ebaid, H., Al-Tamimi, J., Hassan, I., Alhazza, I., & Al-Khalifa, M. (2014). Antioxidant bioactivity of Samsum ant (Pachycondylasennaarensis) venom protects against CCL 4-induced nephrotoxicity in mice. Oxidative Medicine and Cellular Longevity, 2014.
Chiu, D. T., Stults, F. H., &Tappel, A. L. (1976). Purification and properties of rat lung soluble glutathione peroxidase. BiochimicaetBiophysicaActa (BBA)-Enzymology, 445(3), 558-566.
Shangari, N., & O'Brien, P. J. (2006). Catalase activity assays. Current protocols in toxicology, 27(1), 7-7.
Pabst, M. J., Habig, W. H., &Jakoby, W. B. (1974). Glutathione S-transferase A: a novel kinetic mechanism in which the major reaction pathway depends on substrate concentration. Journal of Biological Chemistry, 249(22), 7140-7148.
Jagetia, G. C., &Baliga, M. S. (2004). The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study. Journal of Medicinal Food, 7(3), 343-348.
Kumar, A., Khushboo, Pandey, R., & Sharma, B. (2020). Modulation of superoxide dismutase activity by mercury, lead, and arsenic. Biological trace element research, 196, 654-661.
Huang, Z., Liu, Y., Mao, Y., Chen, W., Xiao, Z., & Yu, Y. (2018). Relationship between glycatedhaemoglobin concentration and erythrocyte survival in type 2 diabetes mellitus determined by a modified carbon monoxide breath test. Journal of Breath Research, 12(2), 026004.
Younis, H. Y., Thanoon, I. A., Fadhil, N. N., &Merkhan, M. M. (2022). Effect of zinc as an add-on to metformin therapy on glycemic control, serum insulin, and c-peptide levels and insulin resistance in type 2 diabetes mellitus patient. Research Journal of Pharmacy and Technology, 15(3), 1184-1188.
Akhtar, M. F. (2021). Anti-Parkinson’s evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals. Frontiers in bioscience-Landmark.
L. D. Devhare, A. P. Ghugare, B. P. Hatwar, D. C. Goupale. Method development for determination of water content from various materials by spectrophotometry and it’s validation. International journal of drug delivery, 2015, 7(4), 233-240.
L. D. Devhare, P. K. Kore. A Recent Review On Bioavailability And Solubility Enhancement Of Poorly Soluble Drugs By Physical And Chemical Modifications. Research chronicle in health sciences. 2016, 2(5), 299-308.
T. U. Tonde, R. H. Kasliwal, L. D. Devhare. Quantitative estimation of bacoside a in polyherbal memory enhancer syrup for memory boosting activity using hptlc method. Research chronicle in health sciences. 2016, 2(6), 315-320.
A. P. Ghugare, L. D. Devhare, B. P. Hatwar. Development and validation of analytical methods for the simultaneous estimation of Nimorazole and Ofloxacin in tablet dosage form. International journal of drug delivery. 2016,8(3), 96-98.
Harshal. G. Salpe, L. D. Devhare, Anjali Ghugre, & Navjot Singh. Formulation and evaluation of hpmc coated diltiazem hcl tablet and its comparison with other marketed preparation. Research chronicle in health sciences. 2016, 3(1), 11-17.
A. A. Makhani and L. D. Devhare. Development and validation of vierordt's spectrophotometric method for simultaneous estimation of drotaverine and nimesulide combination. Research chronicle in health sciences. 2017, 3(2), 22-28.
A. A. Makhani and L. D. Devhare. Development and validation of analytical methods for drotaverine and nimesulide combination. Research chronicle in health sciences. 2017, 3(3), 40-44.
Gayatri Katole, L. D. Devhare et al. Recent insight into some emerging natural resources with remarkable hepatoprotective potentials. International journal of pharmaceutical science and research. 2020, 5(1),41-47.
Vaibhav P Uplanchiwar, Sushil Yadaorao Raut, Lalchand D Devhare, et al. Pharmacological assessment of antiulcer activity of gloriosa superba linn tubers in experimentally induced gastric ulcers. Journal of medical pharmaceutical and allied science. 2021, 10( 3), 2852-2856.
Lalchand D. Devhare and Niharika Gokhale. Acid Neutralizing capacity and antimicrobial potential of selected solvent extract from various indigenous plant. Journal of Advanced Scientific Research (JASR). 2021, 12(4), 175-179.
Lalchand D. Devhare and Niharika Gokhale. Antioxidant and antiulcer property of different solvent extracts of cassia tora linn. Research journal of pharmacy and technology. 2022, 15(3), 1109-1113.
Lalchand D. Devhare and Niharika Gokhale. In silico anti-ulcerative activity evaluation of some bioactive compound from cassia tora and butea monosperma through moleculer docking approach. International journal of pharmaceutical sciences and research. 2023, 14(2), 1000-08.
Lalchand D. Devhare and Niharika Gokhale. A brief review on: phytochemical and antiulcer properties of plants (fabaceae family) used by tribal people of gadchiroli maharashtra. International journal of pharmaceutical sciences and research. 2023, 14(4), 1572-1593
Nikam Nikita R, Akotkar Vaishnavi, Devhare Lalchand, et al. Parenteral drug delivery approach: an overview. Journal of xidian university. 2023, 17(1), 386-400.
Shubham M. Shende , Pooja Bhandare, Lalchand Devhare, et al. In-vitro: micropropagation of mint and investigate the antibacterial activity of mint extract. Eur. Chem. Bull. 2023, 12(Special Issue 5), 780 – 784
Shishupal S. Bodhankar, Lalchand D.Devhare, et al. Formulation and in vitro evaluation of dental gel containing ethanglic extract of Mimosa Pudica. Eur. Chem. Bull. 2023, 12(5), 1293-1299
Lalchand D. Devhare, Shishupal S. Bodhankar, et al. Important role of food and nutritional security during Covid-19: A survey. Eur. Chem. Bull. 2023, 12(5), 1363-1374
Neha R. Pathak, Lalchand D. Devhare, et al. Aclinial reveiew on pharmacological evaluation of Thiazolidine and Isatin in the new millenium as magic moieties. Eur. Chem. Bull. 2023, 12(5), 3410-3417.
Shailja Singh, Kimee Hiuna Minj, Lalchand D Devhare, et al. An update on morphology, mechanism, lethality, and management of dhatura poisoning. Eur. Chem. Bull. 2023, 12(5), 3418-3426.
Pravin B. Suruse, B. A. Jadhav, Lokesh G. Barde, Lalchand D Devhare et al. Exploring the potential of Aerva Lanata extract in a herbal ointment for fungal infection treatment. Journal of Survey in Fisheries Sciences. 2023, 10(1), 1922-1932
Shubham Shende, Bhagyashri Meshram, Heera Karemore, Lalchand D Devhare. et al. Development And Characterization of Glycerogelatin Suppositories For Enhanced Efficacy. European Journal of Pharmaceutical and Medical Research. 2023, 10(6), 522-528
Vinod M. Thakare, Shraddha A. Umare, Lalchand D Devhare et al. Separation and purification of carboxymethyl cellulose from Spinacia Oleracea for use in pharmaceutical dosage form. Eur. Chem. Bull. 2023, 12(5), 4062-4080.
Pravin B. Suruse, Aakansha P. Deshmukh, Lokesh G. Barde, Lalchand D Devhare et al. Rimegepant-embedded fast dissolving films: A novel approach for enhanced migraine relief. Journal of Survey in Fisheries Sciences. 2023, 10(1), 2071-2084
Mahesh Prasad, Abhishek Suman, Swati Srivastava, Lalchand D Devhare et al. Butea monosperma stem bark extract partially reverses high fat diet-induced obesity in rats. Eur. Chem. Bull. 2023, 12(5), 4267 - 4273
Akshaykumar B Kadam, Lalchand D Devhare, Smita T Kumbhar, et al. In-Silico Molecular Docking Study of Substituted Imidazo 1,3,4 Thiadiazole Derivatives: Synthesis, Characterization, And Investigation of Their Anti-Cancer Activity. Journal of Coastal Life Medicine. 2023, 2(11), 1237-1245.
Mamta Shukla, Shital A Tiware, Sanjeevani R Desai, Lalchand D Devhare. et al. Pharmacological Evaluation of Gloriosa Superba Linn Flower Extract For Antiulcer Activity. Journal of Survey in Fisheries Sciences. 2023, 10(2) 463-470.
Papagatla Polireddy, Vedanshu Malviya, Lalchand D Devhare. et al. Assessment of Hepatoprotective Potential of Ecbolium Linneanum Extract on Experimental Animals. Journal of Coastal Life Medicine. 2023, 2(11) 884-890
Ruchi Tiwari, Juhi Mishra, Lalchand Devhare, Gaurav Tiwari. An updated review on recent developments and applications of fish collagen. Pharma Times. 2023, 55(6), 28-36
Konda VVS Krishna, Pushpendra Kumar Jain, Lalchand D Devhare. et al. A Study on Antidiabetic Potential of Dried Fruits Extract of Eucalyptus Globulus in Experimental Animals. Journal of Biomedical Engineering. 2023, 40(3), 99-110
Tiwari, G., Gupta, M., Devhare, L. D., & Tiwari, R. (2023). Therapeutic and Phytochemical Properties of Thymoquinone Derived from Nigella Sativa. Current Drug Research Reviews.
Anil K. Adimulapu, Lalchand D. Devhare, Anasuya Patil, Nilesh O. Chachda, G. Dharmamoorthy(2023). Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases. International Journal of Drug Delivery.Technology. 2023;13(3):801-806
Chawla A, Devhare LD, Dharmamoorthy G, Ritika, Tyagi S. Synthesis and In-vivo Anticancer Evaluation of N-(4-oxo-2- (4-((5-aryl-1,3,4 thiadiazole-2yl) amino) Phenyl thiazolidine-3-yl) Benzamide derivative. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):470-474.
Gnana RPM, Devhare LD, Dharmamoorthy G, Khairnar MV, Prasidha R. Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):475-480.
Sonule M, Devhare LD, Babu MN, Gunjal SD, Varalaxmi S. Microemulgel-based Hydrogel of Diclofenac Sodium using Lipidium sativum as a Gelling Agent. International Journal of Drug Delivery Technology. 2023;13(4):1235-1239.
Shriram BK, Devhare LD, Mehrotra A, Deokar SS, Singh SP. Formulation and Evaluation of Mosquito Repellent Stick. International Journal of Drug Delivery Technology. 2023;13(4):1283-1286.