A Novel Delivery Of Ketoprofen Loaded Gastroretentive Mucoadhesive Nanoparticles Fabricated By Gelatin/Pluronic F68 For The Management Of Rheumatoid Arthritis
Article Sidebar
Main Article Content
Abstract
A promising medication delivery method that can target specific medications at the absorption site is the use of mucoadhesive nanoparticles. This experiment was conducted to develop mucoadhesive gastroretentive ketoprofen nanoparticles, a non-steroidal anti-inflammatory medicine used to treat rheumatoid arthritis (RA).
To carry out the research, a new experimental design was fabricated. This new design made use of a three-factor, two-level central composite. The desolvation procedure was applied to generate nanoparticles that are mucoadhesive and gastroretentive. The formulations were evaluated by various preliminary parameters and transmission electron microscopy(TEM), Fourier-transform infrared spectroscopy (FTIR), zeta potential, particle size, and entrapment efficiency.
To ascertain the adhesion characteristics and release kinetics of the improved batch, in vitro drug release and ex-vivo mucoadhesion tests evaluation were conducted. The idea was to develop a formulation that would enable the stomach to deliver drugs continuously. Keeping therapeutic drug levels in the stomach for a longer period may be used to treat RA symptoms effectively.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Gruber P, Longer MA, Robinson JR, Some biological issues in oral, controlled drug delivery. Adv Drug Delivery Rev 1987;1:1-18.
Mathur P, Jhawat V, Dutt R. New Insights into Gastroretentive Dosage Forms in Delivery of Drugs. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine). 2021 Jul 1;11(2):91-101.
Pallavi S, Patil SV, Patil SS, Shinde S. Preparation and evaluation of mucoadhesive nanoparticles of rosuvastatin. Indian Journal of Pharmaceutical Sciences. 2018 May 31;80(3):428-33.
Nikalje AP, Tiwari S, Kamble S. Mucoadhesive: As Oral Controlled Gastroretentive Drug Delivery System. International Journal of Research in Pharmacy & Science. 2012 Jul 1;2(3).
Farhadnejad H, Mortazavi SA, Jamshidfar S, Rakhshani A, Motasadizadeh H, Fatahi Y, Mahdieh A, Darbasizadeh B. Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System. Iranian Journal of Pharmaceutical Research: IJPR. 2022 Dec;21(1).
Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. International journal of pharmaceutics. 2003 Apr 14;255(1-2):13-32.
Adibkia K, Ghanbarzadeh S, Mohammadi G, Atashgah RB, Sabzevari A. Gastro retentive Drug Delivery System : A Review. IJRPS 2013:2;190-204.
Sarparanta MP, Bimbo LM, Mäkilä EM, Salonen JJ, Laaksonen PH, Helariutta AK, Linder MB, Hirvonen JT, Laaksonen TJ, Santos HA, Airaksinen AJ. The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems. Biomaterials. 2012 Apr 1;33(11):3353-62.
Khramtsov P, Kalashnikova T, Bochkova M, Kropaneva M, Timganova V, Zamorina S, Rayev M. Measuring the concentration of protein nanoparticles synthesized by desolvation method: Comparison of Bradford assay, BCA assay, hydrolysis/UV spectroscopy and gravimetric analysis. International Journal of Pharmaceutics. 2021 Apr 15;599:120422.
Carvalho JA, Abreu AS, Ferreira VT, Gonçalves EP, Tedesco AC, Pinto JG, Ferreira-Strixino J, Beltrame Junior M, Simioni AR. Preparation of gelatin nanoparticles by two step desolvation method for application in photodynamic therapy. Journal of Biomaterials Science, Polymer Edition. 2018 Jul 24;29(11):1287-301.
Mishra AK, Neha SL, Rani L, Dewangan HK, Sahoo PK. QbD assisted development and validation of UV spectroscopic method in estimation of silymarin. Lett. Drug Des. Discov. 2023;20.
Bansal M, Verma R, Mittal V, Kaushik D. Central Composite design for the development and evaluation of floating-mucoadhesive tablets of gliclazide. Current Drug Therapy. 2021 Feb 1;16(1):113-23.
Kharia AA, Singhai AK. Screening of most effective variables for development of gastroretentive mucoadhesive nanoparticles by Taguchi design. International Scholarly Research Notices. 2013;2013.
Hassan, Haniza et al. "Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir." Molecules (Basel, Switzerland) vol. 26,18 5432. 7 Sep. 2021, doi:10.3390/molecules26185432
Rençber, Seda et al. "Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis." International journal of nanomedicine vol. 11 2641-53. 10 Jun. 2016, doi:10.2147/IJN.S103762
Date PV, Samad A, Devarajan PV. Freeze thaw: a simple approach for prediction of optimal cryoprotectant for freeze drying. Aaps Pharmscitech. 2010 Mar;11:304-13.
Hassan H, Adam SK, Alias E, Meor Mohd Affandi MMR, Shamsuddin AF, Basir R. Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir. Molecules. 2021; 26(18):5432.
Tran TH, Ramasamy T, Choi JY, Nguyen HT, Pham TT, Jeong JH, Ku SK, Choi HG, Yong CS, Kim JO. Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells. International journal of nanomedicine. 2015;10:5249.
Kumari V, Tyagi P, Sangal A. In-vitro kinetic release study of illicium verum (Chakraphool) polymeric nanoparticles. Materials Today: Proceedings. 2022 Jan 1;60:14-20.
Bohrey, S., Chourasiya, V. & Pandey, A. Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study. Nano Convergence 3, 3 (2016).
Pallavi S, Patil SV, Patil SS, Shinde S. Preparation and evaluation of mucoadhesive nanoparticles of rosuvastatin. Indian Journal of Pharmaceutical Sciences. 2018 May 31;80(3):428-33.
Patil SK, Joshi SR, Patil SV, Patil SS, Nitave SA. Design and characterization of mucoadhesive microsphere of antiinflammatory drug. Int J Pharm Sci Res 2014:5:865-77
Kharia AA, Singhai AK. Development and optimization of mucoadhesive nanoparticles of acyclovir using design of experiments approach. Journal of microencapsulation. 2015 Aug 18;32(6):521-32.
Yadav HKS, Nagaverma BVN, Ayaz A, Vasudha LS, Shivkumar HG. Different techniques for preparation of polymeric nanoparticles. A review. Asian J Pharm Clin Res 2012;5:16-23.
Shinde SS, Hosmani AH. Preparation and evaluation lipid nanoparticles of Fenofibrate obtained by spray drying technique. Pharmacophore 2014;5:85-93.
Parmar, A., Kaur, G., Kapil, S., Sharma, V., & Sharma, S. (2019). Central composite design-based optimization and fabrication of benzylisothiocynate-loaded PLGA nanoparticles for enhanced antimicrobial attributes. Applied Nanoscience. doi:10.1007/s13204-019-01185-0.
Mathur P, Jhawat V, Dutt R. New Insights into Gastroretentive Dosage Forms in Delivery of Drugs. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine). 2021 Jul 1;11(2):91-101.
Singh C, Yashwant, Gupta AK, Garg V. Formulation Development and Evaluation of Divalproex Sodium Extended-release Tablets. International Journal of Drug Delivery Technology. 2022;12(4):1769-1773.DOI: 10.25258/ijddt.12.4.46